Hello John, One of our developers commented that this looks like a polymorphism:
To see this go to chr11:61,165,728-61,165,752 on hg19 and turn on the "All SNPs(132)" (variation group) and "Human mRNAs" (mRNA and EST group) tracks on full. Then go to the description page for the "Human mRNAs" track (either by clicking on the gray bar to the left of the track or clicking on the track title above the pulldown menu) and for the "Color track by codons or bases:" option select "different mRNA bases". Now in the main display you should see base differences for BC011010 and AF151078. This polymorphism results in a 3 AA indel in the protein just one AA before the C-terminus. Hopefully this information was helpful and answers your question. If you have further questions or require clarification feel free to contact the mailing list at [email protected]. Best regards, Pauline Fujita UCSC Genome Bioinformatics Group http://genome.ucsc.edu On 5/4/11 6:13 AM, Walsh, John wrote: > Hello All, > > There seems to be a discrepancy between the Genbank Nucleotide mRNA for this > gene , Human TMEM216, and the '3 end of block 4 and 5' beginning of block 5 > (the splice sites). Was this intentional to maintain typical splice site > bases? > > Thanks for any insight. > > > John P. Walsh > Scientist > Athena Diagnostics, Inc. > A Thermo Fisher Company > 377 Plantation Street > Worcester, MA 01605 > (508) 756-2886 x3134 > (508) 753-5601 (fax) > [email protected] > > _______________________________________________ > Genome maillist - [email protected] > https://lists.soe.ucsc.edu/mailman/listinfo/genome > _______________________________________________ Genome maillist - [email protected] https://lists.soe.ucsc.edu/mailman/listinfo/genome
