Hello Will, Thank you for your offer of data. I will contact you off-list with more details/questions.
Regards, ---------- Ann Zweig Technical Project Manager, UCSC Genome Browser http://genome.ucsc.edu On 12/19/11 1:18 PM, William Ray wrote: > > Asking an almost FAQ question here... > > A colleague and I are writing a proposal with the goal of significantly > increasing the annotation density for functional SNPs in human brain. > > A literature review of the area highlights several peculiar features of the > psychiatric genetics field: research in the area is dramatically dominated > by analyses of functional SNPs; there is a dearth of annotated > brain-functional SNPs resulting in more than half of the publications in the > area discussing the same 10 genes (and several of these aren't > brain-functional); and finally, the few studies that go beyond these have > done nothing to push their functional-SNP discoveries out to other > researchers. resulting in new appealing targets going unrecognized and > unexplored. > > We possess several unique resources including a significant brain brain bank, > detailed psycho-behavioral metric data, and a unique statistical method for > sequentially updating functional analyses as new data becomes available, > without requiring re-analysis of previously acquired data. Using these, we > propose to develop a much denser annotation of SNPs with demonstrated > function in brain tissue, and to distribute this to the community. Further, > we intend to develop a resource where future eQTL studies can be incorporated > into the analysis thereby providing a mechanism for uniform dissemination of > other researcher's results as well. > > We would like to know if you would be interested in carrying this annotation > track as a standard feature in the UCSC Genome Browser. We firmly believe > that the lack of such a uniform repository, and the relative lack of > computational data-sharing accent in the currently extant projects, is one of > the most significant impediments to the field of psychiatric genetics. We > further believe that demonstrating a firm commitment to closing the loop and > pushing our data back to the community, through a mechanism such as the UCSC > browser, would be recognized as a significant feature of our proposal. > > Of course, we understand that numerous format, content, and logistic details > would need to be worked out, but we have excellent programming staff and have > no concerns regarding our ability to do the heavy lifting, if you would be > interested in hosting the track once completed. > > > Many thanks for your time and attention, > > Will Ray > Chris Bartlett > Nationwide Children's Hospital > The Ohio State University Biophysics Program > > > _______________________________________________ > Genome maillist - [email protected] > https://lists.soe.ucsc.edu/mailman/listinfo/genome _______________________________________________ Genome maillist - [email protected] https://lists.soe.ucsc.edu/mailman/listinfo/genome
