In my current litter of five, at birth and in the early weeks there was
no runt.  However, now that they are just about four weeks old the
argente cream pup is noticably smaller than the rest and "frailer", too,
e.g., in her ability to climb and stength/balance to do other physical
things.

Should I be concerned and do something? (see seems to be eating and
drinking well)  Will she catch up to the rest of the litter?

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