ag1805x commented on issue #45645:
URL: https://github.com/apache/arrow/issues/45645#issuecomment-2692390824

   Hello @amoeba! Each group, by combining `sample_id, gene1, gene2`, will have 
10 rows each. What I understood is it is the `filter()` within `mclappy` that 
is the current bottleneck. I tried chunking the `grp_list` and then filtering, 
but it is the same issue.
   
   Do you suggest using `to_duckdb()` before or after the `filter` or 
`collect`? 


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