ketamine
(Ketamine Hydrochloride Special K, K)
Also see: urban75 Ketamine info in the House Of Commons!
Ketamine is a short-acting general anaesthetic that has hallucinogenic and painkilling qualities that seem to affect people in very different ways.
First used as a recreational drug in 1965, ketamine - that's 2-(2-chlorophenyl)-2-(methylamino)- cyclohexanone chemcial fans - most commonly comes as a powder, but can also be seen in liquid and tablet form.
Some people describe a speedy rush within a few minutes of sniffing the powder (20 minutes if taken as a pill, quicker if injected), leading to powerful hallucinations and even out of body experiences (the 'K Hole'), along with physical incapacitation.
If you're on a dancefloor, music can sound heavy, weird and strangely compelling, lights seem very intense and physical co-ordination can fall apart along with an overall feeling of numbness.
Some people feel paralysed by the drug, unable to speak without slurring, while others either feel sick or throw up.
Be extremely careful how much Ketamine you take - it's stronger than the same amount of speed or coke and the more you wolf down, the stronger the effects.
Accept that you may well be in for a rough ride with the drug as its effects are unpredictable and sometimes very confusing. Try not to mix it with other drugs, particularly alcohol.
Make sure you take it in a safe environment with friends who know what you're up to. Remember it's an anaesthetic, so if you hurt yourself you may not feel any pain. Like all drugs, it's best to be in good mental and physical health before taking anything.
Side effects: Ketamine blocks nerve paths without depressing respiratory and circulatory functions, and therefore acts as a reliable anaesthetic. This may turn you into a gibbering, spaced out bore, mumbling and slurring away while your dancing may begin to resemble Bill and Ben on acid. Your movements may become as swift as a spliffed-up tortoise crawling across an extra-sticky big bun on a very hot day. You may be unable to move at all.
Health risks: No one knows what the long-term effects of taking ketamine regularly are. Because of its anaesthetic qualities, people have been known to hurt themselves and not realise until the following day. Ketamine should not be taken with respiratory depressants, primarily alcohol, barbiturates, or Valium and because of the uncertain interaction with other drugs, it is advised not to mix ketamine with anything. Large doses could induce unconsciousness which could lead to cardiovascular failure. Although not physically addictive, some users have a developed a strong habit.
A BBC report in May 2000 claimed that medical research had shown that controlled tests on ketamine users had revealed impaired memory and mild schizophrenia several days after taking the drug.
There have been media reports of Ketamine being used as a 'date rape' drug. Make sure you take it with at least one 'straight' friend around.
The Law: Ketamine was classified as a Class C drug under the Under the Drugs Act 2005, with the legislation taking effect from 1st Jan, 2006.
FACT!
The urban75 guide to k ingestion (if k is your thing - it's not ours)
Where k is great!
If you're having a party in your own house - sure. Enjoy! Snort away. But play safe and only take it if you're in an ultra safe environment.
If you're having a party in someone else's house and they all love k - go for it!
Where k is bad
If you're visiting a friend's bar/club, don't put them in a situation where they have to explain to the owner why one of your friends is a gormless oddity.
If you're visiting someone's party and no one's doing k, show some respect and don't do it. After all, it's a party for people to talk, dance and have fun, not a place for you to self-indulgently examine your inner psyche in a slumbering heap on the dance floor.
If you've been invited around a friend's house for a late drink, keep the k to yourself: it's anti-social, self indulgent and, frankly, what right have you to inflict your monged out, incoherent presence on an affable host?
More info:
» urban75 Ketamine info in the House Of Commons!
» drug assisted sexual assault - advice on prevention
Drogas atuais demoram semanas para aliviar sintomas da da depressão Cientistas americanos dizem que a droga anestésica ketamina pode tratar a depressão em algumas horas.Eles fizeram um estudo com 17 pacientes sofrendo de depressão severa que haviam sido tratados, sem sucesso, com pelo menos dois tipos de anti-depressivos.
Segundo os cientistas do National Institute of Health em Bethesda, Maryland, nos Estados Unidos, os efeitos benéficos da ketamina foram sentidos em menos de duas horas e duraram cerca de uma semana.
O estudo foi publicado na revista Archives of General Psychiatry.
A maioria dos tratamentos atuais para depressão demora semanas e até meses para aliviar os sintomas.
A droga ketamina é um poderoso anestésico usado em humanos e animais. Ela também é usada como droga recreativa.
Para o estudo, os voluntários foram injetados alternadamente com ketamina ou com um placebo.
Os pesquisadores mediram os índices de depressão dos participantes minutos, horas e dias após as injeções.
O coordenador da pesquisa, Carlos Zarata Jr, disse: "Dentro de 110 minutos, a metade dos pacientes que receberam ketamina mostrou uma diminuição de 50% nos sintomas".
No final do primeiro dia, 71% dos voluntários mostraram sinais de melhora. E 29% deles ficaram livres de sintomas.
Os pesquisadores também descobriram que, para mais de um terço dos participantes, o efeito de uma dose durou ao menos uma semana.
Muitos antidepressivos atuam sobre substâncias presentes no cérebro como a seratonina e a dopamina, mas seu efeito só começa a ser sentido depois de várias semanas.
Os pesquisadores americanos acreditam que a ketamina tem um efeito mais rápido porque age sobre uma proteína diferente, o receptor NMDA, que estaria associada ao aprendizado e à memória.
Mas, segundo os cientistas, a droga não poderia ser usada na forma atual por causa dos efeitos colaterais de doses altas, entre eles, alucinações e euforia.
"Esse estudo é um instrumento para nos ajudar a entender qual parte da ketamina está causando o efeito, para que possamos refinar e desenvolver drogas melhores", disse Zarate.
"Estamos também procurando formas de usar a ketamina, talvez em doses mais baixas ou em conjunto com drogas que bloqueiem seus efeitos na percepção, para que possamos administrá-la clinicamente", acrescentou.
Comentando o estudo, o professor de toxicologia John Henry, do hospital St. Mary's, em Londres, disse que o estudo é promissor.
Para ele, uma droga de efeito mais rápido traria muitos benefícios.
"As pessoas poderiam voltar ao trabalho mais rápido, e (a droga) também reduziria o risco de suicídio e auto-abuso", disse.
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