Hello Andre, It seems to be setup correctly for pointing your sub-domain *courses.reframe.space* to your app. The public <https://www.whatsmydns.net/#CNAME/courses.reframe.space> DNS records also indicate you've added the required CNAME record. It it's still not working, you're probably enforcing SSL on your application but have no valid certificate added <https://cloud.google.com/appengine/docs/python/console/using-custom-domains-and-ssl#adding_ssl_to_your_custom_domain> through the console.
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