We've had a set of users that have discovered an issue with their latest 
datasets that I'm hoping there might be a best practice for dealing with in 
regards to FSL.

I've received some specific context from the end users on what they are 
capturing:
Users are collecting single-band spin echo EPI images in opposing phase encode 
directions with the CMRR sequence (cmrr_mbep2d_se) on our 3T Prisma to provide 
means of correcting for susceptibility distortions via FSL’s ‘TOPUP’ tool. 
Their protocol parameters closely follow what is specified in the HCP Q3 
Release Appendix I. The dicom output of this data is UINT16 which isn’t 
supported by nifti 1.0 format. Is there a recommended solution that would play 
nice with FSL (TOPUP in particular) ? With the dcm2nii conversion tool, we can 
either go ahead and set the data type to UINT16 or set it to float32, but is 
there a specific recommendation from your end?

I've verified the values using the MRICron tool to visually inspect values and 
they are infact overflowing into negative numbers so we have a few options: 
Force unit16 (out of standard), force Float32 (in standard but larger, slower, 
and brings along the baggage of float numbers), divide all intensities by 2 
(lossy, I don't regard it as an acceptable solution for raw data), or fall back 
on dicom files (I'm not clear if this is supported by FSL).

Any suggestions or feedback would be appreciated.

Garrett McGrath
HPC and Research Computing
Princeton Neuroscience Institute, Princeton University
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