I don't know what PFA is and am otherwise having some trouble following your 
question.  There is grand mean intensity normalization to 10000, meaning that 
the entire 4D image inside the brain mask has a mean of 10000.

Peace,

Matt.

From: 
<hcp-users-boun...@humanconnectome.org<mailto:hcp-users-boun...@humanconnectome.org>>
 on behalf of mali s <s.malisun...@gmail.com<mailto:s.malisun...@gmail.com>>
Date: Monday, November 21, 2016 at 8:08 PM
To: "hcp-users@humanconnectome.org<mailto:hcp-users@humanconnectome.org>" 
<hcp-users@humanconnectome.org<mailto:hcp-users@humanconnectome.org>>
Subject: [HCP-Users] 4D Intensity normalization in the fMRIVolume pipeline

Dear HCP team,

We are using minimally preprocessed volume files from HCP database 
(100206/MNINonLinear/Results/tfMRI_MOTOR_LR/tfMRI_MOTOR_LR.nii). The release 
notes for this subject say these files were processed using v3+ of the 
pipeline. I believe 4d intensity normalization to mean of 10^4 is being done 
here.

However, PFA the mean brain activation (after applying mask) during the course 
of the scan . They are all close to 10^4,  more like a global signal 
normalization for every 3d volume.

I am having trouble reconciling both. Thanks in advance for the help.

Regards,
Mali



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