Dear Matt,

I completed all three structural pipelines and performed PALM comparison
for myelin maps. However, the result I got was somewhat opposed to
expectations (patients with early MS having significantly stronger
myelination compared to healthy controls).
I wondered that maybe something in our acquisition technique could have
caused an error in the calculation (as they are a bit different from the
HCP protocol)? I used the following images:

3D MPRAGE (TR = 1900 ms, TE = 2.55 ms, TI = 900 ms, flip angle = 90 , FOV =
240 x 240 mm2 , matrix size = 240 x 240, 176 slices, slice thickness = 1
mm), no fat suppression
T2 SPACE (same matrix, FOV, and number of slices as in the T1w, TR=5000ms,
TE= 393ms, flip angle = 120, slice thickness = 1mm), no fat suppression

Is there anything that would have cause imprecise calculation of myelin
maps or is it just how our results are?

Thanks a lot!!

Lisa

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