I think I've posted to Histonet on this subject before, with no response - about amyloid controls. Amyloid control tissue is extremely hard to get, since amyloidosis is quite a rare disease, and very few autopsies are performed these days. Controls I've seen lately are usually from surgically resected medullary thyroid carcinomas, but this is a rare disease also, and something of an off-brand amyloid (formed from calcitonin) is present in only about 25% of them. The need to cut fresh sections every time means that blocks are quickly exhausted.
Amyloidosis of the AA type is rather easily induced in mice - see http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIGMA/A2765 for a little information and a brief bibliography (I have no connection with Sigma-Aldrich). I would think that this mouse tissue containing amyloid could be used as a control. Does anyone use it? Bob Richmond Samurai Pathologist Knoxville TN _______________________________________________ Histonet mailing list Histonet@lists.utsouthwestern.edu http://lists.utsouthwestern.edu/mailman/listinfo/histonet