The following was taken from the NCCI manual, Chapter 10, effective 1/1/14:

9. The unit of service for in situ hybridization reported as CPT codes 88365, 
88367, or 88368 is each probe staining procedure per specimen. If a single 
probe staining procedure for one or more probes is performed on multiple blocks 
from a surgical specimen, multiple slides from a cytologic specimen, or 
multiple slides from a hematologic specimen, only one unit of service may be 
reported for each separate specimen. Physicians should not report more than one 
unit of service for CPT codes 88365, 88367, or 88368 per specimen for a probe 
staining procedure even if it contains multiple separately interpretable probes.

I'm wondering how other labs are interpreting this, because I'm not sure how we 
continue to offer FISH testing and not go "in the hole" financially, if we can 
only bill for ONE probe on ONE specimen, regardless of the actual number of 
interpretable probes (Example: currently, for a HER2 FISH test, we bill for 2 
units of service--1 for the HER2 probe and 1 for the CEP17 probe--both of which 
have to be enumerated by a professional and a ratio generated). Any insight 
from others would be greatly appreciated....Thanks!


Jill A. Johns, MT(ASCP)SH, QCym, CCy
Manager of Molecular Pathology
Central PA Alliance Laboratory (CPAL)
1803 Mt. Rose Ave., Suite C3/C4
York,  PA    17403
phone: (717) 851-4320
fax:  (717) 851-1450
email:  jjoh...@cpallab.com<mailto:jjoh...@cpallab.com>


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