Thank you Dr. Cartun, these numbers are helpful for reference
Joelle Weaver MAOM, HTL (ASCP) QIHC > From: richard.car...@hhchealth.org > To: one...@wvuhealthcare.com; histonet@lists.utsouthwestern.edu > Date: Fri, 14 Mar 2014 20:01:54 +0000 > CC: > Subject: [Histonet] RE: CAP Annual Results Comparison for FISH/ISH > > I'm not aware of published benchmarks for FISH/ISH, but if you're doing IHC > for ER, PR, and HER2 in breast CA you may find the following information > useful: > > Lal P, et al: ER and PR and histologic features in 3,655 invasive breast > carcinomas. Am J Clin Pathol 2005;123:541-546. > > ER+ tumors - 74% > PR+ tumors - 49 > HER2+ tumors - 16% > > > Fitzgibbons PL, et al: Recommendations for validating ER and PR IHC assays. > Arch Pathol Lab Med 2010;134:930-935. > > For women over 65 years of age, the % of negative cases should not exceed 20%. > For "low-grade" invasive carcinomas, the proportion of negative cases should > not exceed 5%. > > > My own data for invasive breast CA: > > ER+ tumors - 85% > PR+ tumors - 70% > HER2+ tumors - 14% > > > Please keep in mind that with the introduction of new monoclonal antibodies, > more sensitive detection systems, and the "recommendation" that tumors with > "1%" immunoreactive cells be called "Positive", the "old" benchmarks for ER > and PR are no longer valid. > > Richard > > Richard W. Cartun, MS, PhD > Director, Histology & Immunopathology > Director, Biospecimen Collection Programs > Assistant Director, Anatomic Pathology > Hartford Hospital > 80 Seymour Street > Hartford, CT 06102 > (860) 972-1596 Office > (860) 545-2204 Fax > richard.car...@hhchealth.org > > > > > -----Original Message----- > From: histonet-boun...@lists.utsouthwestern.edu > [mailto:histonet-boun...@lists.utsouthwestern.edu] On Behalf Of O'neil, Beth > Sent: Wednesday, March 12, 2014 2:41 PM > To: histonet@lists.utsouthwestern.edu > Subject: [Histonet] CAP Annual Results Comparison for FISH/ISH > > Would fellow Histonetters be able to explain how they answer the following > CAP question: > ANP.22970 For immunohistochemical and FISH/ISH tests that provide independent > predictive information, the laboratory at least annually compares its patient > results with published benchmarks, and evaluates interobserver variability > among the pathologists in the laboratory. > Where would one even find published benchmarks? Thank you > > Beth Ann O'Neil, MT(ASCP)SC, HTL, QIHC > Histology Supervisor/Technical Specialist West Virginia University Hospitals > one...@wvuhealthcare.com > 304-293-7629 (office) > 304-293-6014 (lab) > > > > > _______________________________________________ > Histonet mailing list > Histonet@lists.utsouthwestern.edu > http://lists.utsouthwestern.edu/mailman/listinfo/histonet > > This e-mail message, including any attachments, is for the sole use of the > intended recipient(s) and may contain confidential and privileged > information. Any unauthorized review, use, disclosure, or distribution is > prohibited. If you are not the intended recipient, or an employee or agent > responsible for delivering the message to the intended recipient, please > contact the sender by reply e-mail and destroy all copies of the original > message, including any attachments. > > _______________________________________________ > Histonet mailing list > Histonet@lists.utsouthwestern.edu > http://lists.utsouthwestern.edu/mailman/listinfo/histonet _______________________________________________ Histonet mailing list Histonet@lists.utsouthwestern.edu http://lists.utsouthwestern.edu/mailman/listinfo/histonet
