Like and Ditto to Joyce. Paula Pierce, BS, HTL(ASCP)HT President Excalibur
Pathology, Inc. 5830 N Blue Lake Dr. Norman, OK 73069 405-759-3953 PH
405-759-7513 FAX www.excaliburpathology.com
From: "Weems, Joyce K." <joyce.we...@emoryhealthcare.org>
To: "Stedman, Nancy" <nancy.sted...@buschgardens.com>; "Adesupo, Adesuyi
(Banjo)" <abades...@nrh-ok.com>; "'histonet@lists.utsouthwestern.edu'"
<histonet@lists.utsouthwestern.edu>
Sent: Monday, July 13, 2015 3:09 PM
Subject: Re: [Histonet] National Academy of Sciences Confirms That
Formaldehyde Can Cause Cancer in a Finding That Has Implications for Anatomic
Pathology and Histology Laboratories
The problem in the clinical world is that many clinical trials require formalin
fixation, so I would not want to substitute anything that would prevent a
patient from being in a trial.
It's not new to me that formalin is a carcinogen. I just try to make sure to
use PPE and have good ventilation and monitor as necessary. (Unlike when I put
my ungloved hands in it and had no ventilation when I started down this path a
hundred years ago.) j
Joyce Weems
Pathology Manager
678-843-7376 Phone
678-843-7831 Fax
joyce.we...@emoryhealthcare.org
www.saintjosephsatlanta.org
5665 Peachtree Dunwoody Road
Atlanta, GA 30342
This e-mail, including any attachments is the property of Saint Joseph's
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-----Original Message-----
From: Stedman, Nancy [mailto:nancy.sted...@buschgardens.com]
Sent: Monday, July 13, 2015 3:12 PM
To: Adesupo, Adesuyi (Banjo); 'histonet@lists.utsouthwestern.edu'
Subject: Re: [Histonet] National Academy of Sciences Confirms That Formaldehyde
Can Cause Cancer in a Finding That Has Implications for Anatomic Pathology and
Histology Laboratories
We are using Excell Plus made by American Master Tech. It is a combination of
alcohol, ethylene glycol, and glyoxal. It does not fix quite as fast as
formalin but fixes just as well as long as tissue samples are small and not too
fatty. We work in veterinary pathology and mostly with necropsy tissues, and
try to keep everything 5 to 10 mm maximum thickness that goes into Excell Plus.
It definitely won't fix an entire intact brain no matter how long you let it
sit so we book the brains into thin slices 24 hours after collection. We have
done some limited IHC and DNA extraction from Excell Plus fixed tissue and have
not had any issues. We tried another low tox fixative too - Statlab's GTF
formalin substitute, which is glyoxal - and it did not fix as well as Excell
Plus. GTF fixed CNS tissues especially had a lot of artifact like shrunken
neurons.
Hope this is helpful. I would also be curious to know how many labs use
formalin substitutes because it seems like they have not caught on much (or at
all) in the veterinary world.
-Nancy
Nancy L. Stedman DVM PhD Dipl ACVP
Veterinary Pathologist
Busch Gardens Tampa
nancy.sted...@buschgardens.com
-----Original Message-----
From: Adesupo, Adesuyi (Banjo) [mailto:abades...@nrh-ok.com]
Sent: Monday, July 13, 2015 12:52 PM
To: 'histonet@lists.utsouthwestern.edu'
Subject: [Histonet] National Academy of Sciences Confirms That Formaldehyde Can
Cause Cancer in a Finding That Has Implications for Anatomic Pathology and
Histology Laboratories
Hi,
I read this article (National Academy of Sciences Confirms That
Formaldehyde Can Cause Cancer in a Finding That Has Implications for Anatomic
Pathology and Histology Laboratories) this morning.
I wanted to know whether some of you guys out there are using Formaldehyde
substitute.
Best regards,
Banjo Adesuyi, BMLS, HT (ASCP) HTL, QIHC, QLS
Histology Supervisor
Norman Regional Health System,
Norman, OK 73071.
Tel: 405- 307- 1145
abades...@nrh-ok.com<mailto:abades...@nrh-ok.com>
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