Hello, Thanks to all who responded to my question. The solution, it seems was very simple.
Several people reported similar experiences and issues with the specimen clamp not fitting tightly and that I should clean the clamp or block. My blocks are clean and I thought the clamp was too... but when I ran a set of forceps along the inner, upper edge of the clamp a tiny blob of wax was found. A test block cut normally. I'm amazed a tiny piece of wax could cause so much trouble! Thanks to everyone who offered help. Bye _______________________________________________ Histonet mailing list Histonet@lists.utsouthwestern.edu http://lists.utsouthwestern.edu/mailman/listinfo/histonet