Be sure stainer is not expired 
John IMEB Inc
Fresh stain less then 1 year old is best option we find

> On Aug 20, 2025, at 10:09 AM, [email protected] wrote:
> 
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> Today's Topics:
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>   1. Nuclear fast red counterstain (Histology)
>   2. Re: Nuclear fast red counterstain (John Kiernan)
> 
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> ----------------------------------------------------------------------
> 
> Message: 1
> Date: Tue, 19 Aug 2025 17:31:00 +0000
> From: Histology <[email protected]>
> To: Histonet <[email protected]>
> Subject: [Histonet] Nuclear fast red counterstain
> Message-ID: <[email protected]>
> Content-Type: text/plain; charset="us-ascii"
> 
> Hi all,
> 
> Has anyone experienced commercially pre-made Nuclear Fast Red having reddish 
> crystals in it?  We use this as a counterstain for Prussian Iron and Melanin 
> stains and we are seeing little crystals on the slide.  We have tried 
> filtering the solution but we are still seeing this problem.  Any help would 
> be much appreciated.
> 
> Thanks as always Histonet!!
> 
> Mehndi Helgren
> Lab Manager
> 757-664-7901
> Dominion Pathology Labs.
> 733 Boush St. Suite 200
> Norfolk, VA  23510
> 
> 
> 
> ------------------------------
> 
> Message: 2
> Date: Tue, 19 Aug 2025 19:32:29 +0000
> From: John Kiernan <[email protected]>
> To: Histology <[email protected]>, Amrit Samra via Histonet
>    <[email protected]>
> Subject: Re: [Histonet] Nuclear fast red counterstain
> Message-ID:
>    
> <yt3pr01mb1082091292c9e6c777c08005ba5...@yt3pr01mb10820.canprd01.prod.outlook.com>
>    
> Content-Type: text/plain; charset="iso-8859-1"
> 
> Insist on a solution made with nuclear fast red powder that has been 
> certified by the Biological Stain Commission. Then you will know the dye 
> really is CI  60760 and also that it works properly as a stain. See 
> https://pubmed.ncbi.nlm.nih.gov/17510813/
> [https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg]<https://pubmed.ncbi.nlm.nih.gov/17510813/>
> Certification procedures for nuclear fast red (Kernechtrot), CI 
> 60760<https://pubmed.ncbi.nlm.nih.gov/17510813/>
> Abstract Nuclear fast red (CI 60760), also known as Kernechtrot, is commonly 
> used in conjunction with an excess of aluminum ions as a red nuclear 
> counterstain following histochemical procedures that yield blue products. The 
> dye has also been used as a histochemical and colorimetric reagent for 
> calcium. Unsatisfactory samples of nuclear fast red are encountered 
> occasionally, and confusion has ...
> pubmed.ncbi.nlm.nih.gov
> See also  https://biologicalstaincommission.org/new-dyes/, and search down 
> the page for the item on nuclear fast red. This includes a warning about 
> products that are sold as "certified" stains but have not been tested by the 
> BSC.
> 
> Hoping this helps.  John Kiernan.
> = = =
> ________________________________
> From: Histology via Histonet <[email protected]>
> Sent: Tuesday, August 19, 2025 12:31 PM
> To: Histonet <[email protected]>
> Subject: [Histonet] Nuclear fast red counterstain
> 
> Hi all,
> 
> Has anyone experienced commercially pre-made Nuclear Fast Red having reddish 
> crystals in it?  We use this as a counterstain for Prussian Iron and Melanin 
> stains and we are seeing little crystals on the slide.  We have tried 
> filtering the solution but we are still seeing this problem.  Any help would 
> be much appreciated.
> 
> Thanks as always Histonet!!
> 
> Mehndi Helgren
> Lab Manager
> 757-664-7901
> Dominion Pathology Labs.
> 733 Boush St. Suite 200
> Norfolk, VA  23510
> 
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> ------------------------------
> 
> End of Histonet Digest, Vol 261, Issue 5
> ****************************************


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