Hello,
I would in addition recommend that you run your MTA on a seperate machine(s). If you do use some form of spam/virus filtering keeping it off the IMAP/POP servers would probably leave you in a better position, both in terms of performance and management.
Seconded, especially if you use SpamAssassin. SpamAssassin works really well for us, but it is a serious memory hog at 17-20MB *per process*, plus 5-8MB shared memory. You won't want to run anything else that's sensitive to RAM consumption on a box that's running SA.
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