Bit Defender is supposed to be the best again for 2015 but I have yet to find anyone who uses any version of it successfully with a screen reader and no sighted assistance. I used it back when I had lots of vision but gave up on it a few years ago when they changed their formatting and went largely to some type of cloud based format that Jaws has difficulty seeing. And now that I have for all practical purposes lost most of my vision have not been using it for years.
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