Angel Herraez wrote:

>Bob Hanson wrote:
>
>  
>
>>that's next. I have an idea but no time to work on it. It would involve 
>>the MOL2 format bond stereochemistry designations.
>>    
>>
>
>I can't find anything about stereochemistry in the MOL2 specs, but 
>MOL has "up", "down", "none" and "nonspecified" bond types (and 
>JChemPaint exports the first 3 into MOL).
>
>  
>
maybe I was thinking "mol"

>>Try at least setting Z values differently for the different atoms. Are 
>>all the H atoms there? It will help a lot if the H atoms are on the 
>>carbons that might otherwise invert.
>>    
>>
>
>I've tested applying this:
>
>bondType = 1 (up)  ==>  Z= 1
>bondType = 6 (down)  ==>  Z= -1
>all the others have Z=0
>
>and although not infallible, it does improve stereo retention during 
>minimization.
>  
>
Good - so then maybe "up from up" gives Z=2? "down from down" gives 
Z=-2? I was thinking about something like that.

>
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-- 
Robert M. Hanson
Professor of Chemistry
St. Olaf College
Northfield, MN
http://www.stolaf.edu/people/hansonr


If nature does not answer first what we want,
it is better to take what answer we get. 

-- Josiah Willard Gibbs, Lecture XXX, Monday, February 5, 1900



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