Hi Rolf,
Thanks very much for your advice. I will look into your suggestions and get
back to you.
Amjad
*AMJAD FAROOQ PhD DIC | Associate Professor
Dept of Biochemistry & Molecular Biology | Miller School of Medicine |
University of Miami | Miami | FL 33136
Located @ Gautier Building #217 | Mail @ 1011 NW 15th Street #217, Miami ,
FL 33136
am...@farooqlab.net | off 305-243-2429 | lab 305-243-9799 | fax
305-243-3955 | www.farooqlab.net*
On Fri, Aug 9, 2013 at 5:43 AM, Rolf Huehne <rhue...@fli-leibniz.de> wrote:
> On 08/08/2013 08:31 PM, Amjad Farooq wrote:
> > Paul,
> >
> > Thanks for your input. But, I do not believe Chimera is a web-based
> > application. I am looking for a web-based application to perform
> mutations.
> >
> Although an external program might not be web-based you could still use
> it for doing the mutation.
>
> With the Jena3D viewer (http://jena3d.fli-leibniz.de) we do something
> similar with Jmol in combination with the 'scap' program from the
> 'jackal' program package for visualizing known variants (SNPs) in
> protein structures (e.g. for PDB code 1DEH).
> Although the amino acid exchanges are usually known beforehand and the
> mutations are precomputed we also do it on-the-fly if no precomputed
> mutants are available.
>
> Since there might be up to several hundred variants known for a single
> structure we only load each mutated residue as a separate model and not
> the whole modeled structure provided by 'scap'.
>
> I currently don't have time to go into more detail but if you are
> interested I could tell you more in about a week.
>
> Regards,
> Rolf
>
> --
>
> Rolf Huehne
> Postdoc
>
> Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI)
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> 07745 Jena, Germany
>
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