You can (if you *really* have to) mutate a String by directly accessing it’s data field like so:
julia> s = "ACTGACTG" julia> s.data[3] = 'A' You’ll run into problems if the characters aren’t all the same size though: julia> a = "∀ x ∈ X" julia> a.data 11-element Array{Uint8,1}: 0xe2 0x88 0x80 0x20 0x78 0x20 0xe2 0x88 0x88 0x20 0x58 Note how the “length” of the string and the data aren’t the same. If you’re using this for some Bio-related stuff there’s https://github.com/BioJulia that might have what you need. — Mike