I am having the same problem, but only after resume from suspend or hibernate. I first thought it was a bluetooth problem, as my bluetooth mouse stops working after a minute or so after resume. However, both the bluetooth adapter is gone (bluetoothctl says "No Default controller"), but also ordinary USB mice will not work.
It seems that HCI dies, and the kernel decides to remove everything else as well. Touchpad works however. I am running 18.04 alpha with 4.16rc3 (4.16.0-041600rc3-generic) mainline kernel. Hardware: Lenovo Thinkpad E580. Full syslog output. BTW: "MX Anywhere 2" is a BT mouse, not a keyboard. Not sure why it is registered as such. Feb 28 14:18:00 miCycle bluetoothd[1040]: Unable to register org.bluez.Battery1 interface for /org/bluez/hci0/dev_E8_02_AE_59_01_F8 Feb 28 14:18:01 miCycle kernel: [13423.017919] input: MX Anywhere 2 as /devices/virtual/misc/uhid/0005:046D:B018.0002/input/input19 Feb 28 14:18:01 miCycle kernel: [13423.018374] hid-generic 0005:046D:B018.0002: input,hidraw0: BLUETOOTH HID v0.09 Keyboard [MX Anywhere 2] on A0:D3:7A:E0:62:A2 Feb 28 14:18:01 miCycle upowerd[1731]: unhandled action 'bind' on /sys/devices/virtual/misc/uhid/0005:046D:B018.0002 Feb 28 14:18:15 miCycle blueman-mechanism: Exiting Feb 28 14:18:42 miCycle kernel: [13464.682662] xhci_hcd 0000:00:14.0: xHC is not running. Feb 28 14:18:42 miCycle kernel: [13464.724396] xhci_hcd 0000:00:14.0: xHCI host controller not responding, assume dead Feb 28 14:18:42 miCycle kernel: [13464.724414] xhci_hcd 0000:00:14.0: HC died; cleaning up Feb 28 14:18:42 miCycle kernel: [13464.746152] usb 1-5: USB disconnect, device number 4 Feb 28 14:18:42 miCycle kernel: [13464.801790] usb 1-6: USB disconnect, device number 3 Feb 28 14:18:42 miCycle systemd[1]: bluetooth.target: Unit not needed anymore. Stopping. Feb 28 14:18:42 miCycle systemd[1]: Stopped target Bluetooth. Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-5/1-5:1.1 Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-5/1-5:1.0 Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-6/1-6:1.1 Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-6/1-6:1.0 Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-5 Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/pci0000:00/0000:00:14.0/usb1/1-6 Feb 28 14:18:42 miCycle acpid: input device has been disconnected, fd 19 Feb 28 14:18:42 miCycle bluetoothd[1040]: Endpoint unregistered: sender=:1.52 path=/MediaEndpoint/A2DPSource Feb 28 14:18:42 miCycle bluetoothd[1040]: Endpoint unregistered: sender=:1.52 path=/MediaEndpoint/A2DPSink Feb 28 14:18:42 miCycle upowerd[1731]: unhandled action 'unbind' on /sys/devices/virtual/misc/uhid/0005:046D:B018.0002 Feb 28 14:18:42 miCycle NetworkManager[879]: <info> [1519823922.9176] bluez5: NAP: removed interface A0:D3:7A:E0:62:A2 -- You received this bug notification because you are a member of Kernel Packages, which is subscribed to linux in Ubuntu. https://bugs.launchpad.net/bugs/1413440 Title: USB stops working after a while (xhci_hcd 0000:00:14.0: Timeout while waiting for setup device command) Status in System76: Triaged Status in linux package in Ubuntu: Triaged Bug description: On my laptop the kernel will sometimes drop the USB hub. After this, the laptop doesn't recognise any device plugged in to the USB ports - plugging and unplugging any device I've tried into any of the USB ports produces no response, not even dmesg entries. Strangely this also applies to bluetooth - it no longer works once USB has dropped (possibly the module is hung of the bus internally). Once this has happened only a reboot fixes it; I've not managed to find any combination of module unload/reload or suspend cycles to reinitialise things correctly. Relevant snippet of dmesg: [48830.625057] xhci_hcd 0000:00:14.0: Timeout while waiting for setup device command [48838.079718] xhci_hcd 0000:00:14.0: Stopped the command ring failed, maybe the host is dead [48838.079742] xhci_hcd 0000:00:14.0: Abort command ring failed [48838.079746] xhci_hcd 0000:00:14.0: HC died; cleaning up [48838.079770] xhci_hcd 0000:00:14.0: Timeout while waiting for setup device command [48838.079806] sched: RT throttling activated [48838.079981] usb 1-1: USB disconnect, device number 16 [48838.079985] usb 1-1.2: USB disconnect, device number 18 [48838.079987] usb 1-1.2.3: USB disconnect, device number 19 [48838.080285] usb 1-1.2.4: USB disconnect, device number 20 [48838.111892] usb 1-1.4: USB disconnect, device number 17 [48838.191292] usb 1-4: USB disconnect, device number 6 [48838.267550] usb 1-10: USB disconnect, device number 8 [48838.282968] usb 2-1: device not accepting address 8, error -62 [48838.282983] usb 2-1: USB disconnect, device number 8 [48838.282986] usb 2-1.2: USB disconnect, device number 9 ProblemType: Bug DistroRelease: Ubuntu 15.04 Package: linux-image-3.18.0-9-generic 3.18.0-9.10 ProcVersionSignature: Ubuntu 3.18.0-9.10-generic 3.18.2 Uname: Linux 3.18.0-9-generic x86_64 ApportVersion: 2.15.1-0ubuntu2 Architecture: amd64 AudioDevicesInUse: USER PID ACCESS COMMAND /dev/snd/controlC1: chris 4255 F.... pulseaudio /dev/snd/controlC0: chris 4255 F.... pulseaudio CRDA: country AU: DFS-UNSET (2402 - 2482 @ 40), (N/A, 20), (N/A) (5170 - 5250 @ 40), (3, 23), (N/A) (5250 - 5330 @ 40), (3, 23), (0 ms), DFS (5735 - 5835 @ 40), (3, 30), (N/A) CurrentDesktop: Unity Date: Thu Jan 22 12:59:27 2015 InstallationDate: Installed on 2013-08-06 (533 days ago) InstallationMedia: Ubuntu 13.04 "Raring Ringtail" - Release amd64 (20130424) MachineType: System76, Inc. Galago UltraPro ProcFB: 0 inteldrmfb ProcKernelCmdLine: BOOT_IMAGE=/vmlinuz-3.18.0-9-generic.efi.signed root=UUID=92c2fa03-f29c-4bcc-87ab-f0fe28c134f2 ro quiet splash vt.handoff=7 init=/lib/systemd/systemd break=mount RelatedPackageVersions: linux-restricted-modules-3.18.0-9-generic N/A linux-backports-modules-3.18.0-9-generic N/A linux-firmware 1.141 RfKill: 1: phy0: Wireless LAN Soft blocked: no Hard blocked: no SourcePackage: linux UpgradeStatus: Upgraded to vivid on 2013-08-06 (533 days ago) dmi.bios.date: 07/09/2013 dmi.bios.vendor: American Megatrends Inc. dmi.bios.version: 4.6.5 dmi.board.asset.tag: Tag 12345 dmi.board.name: Galago UltraPro dmi.board.vendor: System76, Inc. dmi.board.version: galu1 dmi.chassis.asset.tag: No Asset Tag dmi.chassis.type: 9 dmi.chassis.vendor: System76, Inc, dmi.chassis.version: galu1 dmi.modalias: dmi:bvnAmericanMegatrendsInc.:bvr4.6.5:bd07/09/2013:svnSystem76,Inc.:pnGalagoUltraPro:pvrgalu1:rvnSystem76,Inc.:rnGalagoUltraPro:rvrgalu1:cvnSystem76,Inc,:ct9:cvrgalu1: dmi.product.name: Galago UltraPro dmi.product.version: galu1 dmi.sys.vendor: System76, Inc. 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