I encountered this recently under Ubuntu 16.04.5 with Linux
4.15.0-65-lowlatency with an AMD A8-3870k APU. In the most recent case
the machine was fine for nearly a week until I was reading a large
amount of data off a usb stick. By moving my mouse receiver to a USB 3.0
port I was able to make the mouse work normally again without having to
reboot.

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https://bugs.launchpad.net/bugs/1787857

Title:
  USB mouse cursor lags after random time of correct behaviour

Status in linux package in Ubuntu:
  Confirmed
Status in rtirq package in Ubuntu:
  Invalid

Bug description:
  I installed Ubuntu Studio 18.04.1 LTS. After the first apt-get update I 
noticed the following behaviour:
  after havig logged in, my USB mouse works normally for about ten seconds, 
then the cursor starts lagging a lot which makes the mouse pretty much unusable.
  The last dmesg always contain lines these: (more in attached file)

  [<000000009e659b0c>] irq_default_primary_handler threaded 
[<00000000fa56edac>] usb_hcd_irq
  [<000000009e659b0c>] irq_default_primary_handler threaded 
[<00000000fe1afb05>] _rtl_pci_interrupt [rtl_pci]
  Disabling IRQ #18

  Out of frustration & curiosity I disabled most autostart apps
  (Settings > Session ... > Autostart) and re-enabled them after
  rebooting. Since then I rarely encounter the lagging cursor. If I open
  Settings > Mouse & Touchpad and toggle any option on/off the cursor
  starts lagging.

  How can make the cursor work reliably?
  Some comment in dmesg mentions "irqpoll" boot option

  Ubuntu Studio 18.04.1
  4.15.0-20-lowlatency #21-Ubuntu SMP PREEMPT

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