Shoot. It looks like this new Pfizer vaccine is still based on the OspA protein.
I am not remotely an anti-vaxxer, but having looked into the risks of chronic Lyme when we first encountered it, I found multiple papers about cross-reactivity between OspA and certain people's immune T cells. (There are specific genetic alleles that are involved, so this is not an issue for most people, but how many people know whether they carry HLA-DR2 or HLA-DR4?) Here are some of the papers: https://www.nejm.org/doi/full/10.1056/NEJM199007263230402 https://rupress.org/jem/article/203/4/961/46438/Antibiotic-refractory-Lyme-arthritis-is-associated https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075570/ They've probably continued to pursue OspA because there was already one approved vaccine (withdrawn from the market), which speeds up the approval process. I was hoping they'd branch out into other surface proteins that don't have this issue. Sadly, I'll pass on the trial and wait until there's more data. -P > From: Leslie Turek <leslie.tu...@gmail.com> > Subject: [LincolnTalk] New Lyme disease vaccine trial just starting > Date: August 9, 2022 at 11:12:46 EDT > To: "<lincoln@lincolntalk.org>" <lincoln@lincolntalk.org> > > > There's a new Lyme disease vaccine that has been developed by Pfizer and they > are looking for volunteers for a phase 3 clinical trial. They need people who > frequently walk outdoors or who have dogs that might bring in ticks. I figure > that covers a large percentage of Lincoln, so there might be some potential > volunteers out there. > > More information about the vaccine here: > https://apnews.com/article/science-health-ticks-73fab8e29f3e2243c2db5bc33b3265e1 > > More information about volunteering for the trial here: > > https://www.valorlymestudy.com/?utm_campaign=digital1&utm_source=continuum&utm_medium=google&utm_content=lyme%20disease%20vaccine&mpt=continuumgoogle > > What To Expect > > You or your child will be randomly assigned to receive the study vaccine or a > placebo (shot with no active ingredient). Neither you nor the study doctor > will know which has been assigned. > > This study will last about 30 months (2 and a half years). During this time, > you or your child will have at least 7 in-clinic study visits, including 4-5 > visits with blood draws. Additional blood samples may be needed if you or > your child develop symptoms of Lyme disease. > > Over the course of the study, participants will need to report any changes in > their health to the study team. > > The study vaccine and study-related procedures will be provided at no cost. > You do not need health insurance to take part in this study. > > Research studies are voluntary, and taking part in a research study is a > personal choice. You or your child may leave the study at any time, for any > reason. -- The LincolnTalk mailing list. To post, send mail to Lincoln@lincolntalk.org. Search the archives at http://lincoln.2330058.n4.nabble.com/. Browse the archives at https://pairlist9.pair.net/mailman/private/lincoln/. Change your subscription settings at https://pairlist9.pair.net/mailman/listinfo/lincoln.
