One possible bottle neck is the receiving mail relay. If you are 
running sendmail I think it spawns a single process to deliver a 
message regardless of the number of recipients. 

I have had the same sort of problem you are experiencing and while 
my mail is not as time critical as yours I wanted to figure out a 
workaround.

What I did is send out a few test e-mails and ran a tail -f on the 
maillog file. By doing that I could tell what mail servers were 
delaying things. Doing it a number of times over the course of a few 
days eliminated - to some degree - temporary problems. What I 
then did was edit the list file and moved the offending e-mail 
addresses to the bottom of the file and I contacted the admins of 
the mail server. I know this isn't very technical but it did work for 
me. Probably not too helpful for a high volume, large subscriber list. 

Brian 

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