I do not use Preview but I understand that there are issues with Preview under 
Yosemite which require to interact twice before you can access the text.

A thing to try, if your wife can see the text, is to print the file, oddly to 
PDF. The OS X print dialogue allows you to print to PDF and this may result in 
another PDF file which is more friendly to Voiceover. Make sure it you give 
another file name.

Alternatively Do you have access to Nisus Writer Pro? This is a paid app but I 
use it on the mac to read PDF.
If the PDFs are inaccessible because they are either  graphics or DRM protected 
you may have to use something like Finereader to access them.

David Griffith 
<--- Mac Access At Mac Access Dot Net --->

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