Configurable. I'd set SMTP_MAX_RCPTS to be fairly high, tho not more than 100 (see Chuq von Rospach's notes on the performance impacts and implications of this setting for more typical MX distributions).
Back in 2000, there was a fairly long thread in mailman-developers about large lists. Start with <http://mail.python.org/pipermail/mailman-developers/2000-May/006795.html> and work your way through.
There's also an interesting message from Chuq to mailman-developers that is more directly related to this issue at <http://mail.python.org/pipermail/mailman-developers/2001-June/008928.html>. In short, he says that you probably want to set SMTP_MAX_RCPTS to be at least 2, and beyond 5 it doesn't seem to buy a whole lot.
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