The Mailman queue runners load your entire list into memory for all operations.
So yes, that is normal for Mailman.
I originally attempted to manage an announce only list with over 150,000 members on a 
1.5GB Redhat but had to give up because these tasks grew to over 130MB each.
I am currently running a 230,000 subscriber announce list split into 76 sub lists 
controlled by an umbrella list.
No indivdual list is greater than 5k-6k.
This all operates thorough a set of python and bash scripts I wrote to control 
subscriptions and unsubscriptions for the sublists
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