Hi Alina,

Mauve is notoriously picky about input file formats. But that said, I just 
downloaded a couple of bacterial genomes via the route you described (not the 
route I normally use), and they were aligned without any problem.

As to getting the sequences via ftp, it has been so long since I set my system 
up to use a dedicated ftp client instead of a web browser for ftp that I don't 
remember the procedure. But I think you can right-click on a filename to 
download the file. For complete genome sequences in FASTA format you want the 
one with .fna as the extension.

If you want to send me one of your problem files, I could take a look at it ... 
no promises, but I might just notice something.

Guy

Dr. Guy Plunkett III
Senior Scientist, Genome Center of Wisconsin
Senior Scientist, DNASTAR
http://www.genome.wisc.edu/information/gplunkett.html


On 9/5/12, Alina Grigorescu wrote:
>Hi everybody,
>
>
>I am trying to run Mauve (in Windows) to compare a de novo assembly with 
>already published genomes of the same bacterial genus and each time I start an 
>alignment, Mauve stops working after a short while and gives some error code 
>(most often 255).
>
>
>I believe there is a problem with the input files but I can't figure out which.
>
>
>I also tried a test run only with genome sequences downloaded from NCBI but 
>the test was unsuccessful as well. My conclusion is that perhaps I don't 
>download the correct files.
>
>
>So to download genome sequence files, I looked for the organism of interest in 
>the "Genome" database from NCBI, then I selected the "Graphics" view, then 
>"Tools">"download">"FASTA". Apparently Mauve did not like the files I got.
>
>I also tried to go on the NCBI FTP site, but there is no option of "download" 
>files. When clicking on a file, a new webpage opens with sequence information. 
>So I tried to copy all the sequence information displayed on the webpage and 
>paste it in a .txt file, then use the .txt file for Mauve alignments. Mauve 
>stopped working.
>
>
>Could anybody please explain me how should I obtain correct genome sequences 
>and file formats that would work with Mauve? Moreover, I would like to know 
>how to get the annotated genome sequences.
>
>
>Thanks,
>
>Alina
>
>
>--
>
>Alina Grigorescu, PhD
><mailto:[email protected]>[email protected]
><mailto:[email protected]>[email protected]
>
>Postodctoral Researcher
>Centre Wallon de Biologie Industrielle
>Universite de Liege
>Sart-Tilman, B40
>Tel: +3243663997
>
>
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