Just upgraded to -current from my local mirror. Was previously working with a 
recent-ish -current (late April or early May)

In /var/log/maillog:

May 17 17:00:29 fabrik smtpd[8370]: info: OpenSMTPD 5.4.3 starting
May 17 17:00:29 fabrik smtpd[23758]: info: startup
May 17 17:00:30 fabrik smtpd[23464]: smtp-in: New session 3c7a8ed5bcd7c87e from 
host 1000@localhost [local]
May 17 17:00:30 fabrik smtpd[6061]: warn: ca -> pony: pipe closed
May 17 17:00:30 fabrik smtpd[29180]: warn: control -> pony: pipe closed
May 17 17:00:30 fabrik smtpd[23758]: warn: parent -> pony: pipe closed
May 17 17:00:30 fabrik smtpd[15221]: warn: lka -> pony: pipe closed
May 17 17:00:30 fabrik smtpd[12014]: warn: queue -> pony: pipe closed
May 17 17:00:30 fabrik smtpd[11724]: warn: scheduler -> control: pipe closed

$ sudo /usr/sbin/smtpd -d -v 
debug: init ssl-tree
info: OpenSMTPD 5.4.3 starting
debug: bounce warning after 4h
debug: using "fs" queue backend
debug: using "ramqueue" scheduler backend
debug: using "ram" stat backend
info: startup [debug mode]
debug: init ssl-tree
debug: ca_engine_init: using RSAX engine support
debug: parent_send_config_ruleset: reloading
debug: parent_send_config: configuring pony process
debug: parent_send_config: configuring ca process
debug: smtp: listen on 127.0.0.1 port 25 flags 0x0 pki ""
debug: smtp: listen on IPv6:fe80::1%lo0 port 25 flags 0x0 pki ""
debug: smtp: listen on IPv6:::1 port 25 flags 0x0 pki ""
debug: smtp: will accept at most 501 clients
debug: init private ssl-tree
debug: queue: done loading queue into scheduler
debug: smtpd: scanning offline queue...
debug: smtpd: enqueueing offline message 
/var/spool/smtpd/offline/1400360297.gGOeYTNHCB
debug: smtpd: offline scanning done
debug: smtp: new client on listener: 0x870670680c0
smtp-in: New session 196f0b916c2465b1 from host 1000@localhost [local]
warn: ca -> pony: pipe closed
warn: lka -> pony: pipe closed
warn: queue -> pony: pipe closed
warn: control -> pony: pipe closed
warn: parent -> pony: pipe closed
warn: scheduler -> queue: pipe closed

$ dmesg
OpenBSD 5.5-current (GENERIC.MP) #132: Fri May 16 10:26:11 MDT 2014
    t...@amd64.openbsd.org:/usr/src/sys/arch/amd64/compile/GENERIC.MP
real mem = 10715041792 (10218MB)
avail mem = 10421043200 (9938MB)
mpath0 at root
scsibus0 at mpath0: 256 targets
mainbus0 at root
bios0 at mainbus0: SMBIOS rev. 2.4 @ 0xe00f0 (73 entries)
bios0: vendor Apple Computer, Inc. version "MP11.88Z.005C.B08.0707021221" date 
07/02/07
bios0: Apple Computer, Inc. MacPro1,1
acpi0 at bios0: rev 2
acpi0: sleep states S0 S1 S3 S4 S5
acpi0: tables DSDT ECDT FACP HPET APIC MCFG SSDT SSDT SSDT SSDT SSDT SSDT SSDT 
SSDT SSDT SSDT SSDT SSDT SSDT SSDT SSDT SSDT SSDT SSD
T SSDT SSDT
acpi0: wakeup devices P2P5(S4) P2P3(S4) ARPT(S4) RP04(S4) UHC1(S3) UHC2(S3) 
UHC3(S3) UHC4(S3) EHCI(S3) AC9M(S4) EC__(S3) NRP4(S4) SR
P1(S4) SRP3(S4)
acpitimer0 at acpi0: 3579545 Hz, 24 bits
acpiec0 at acpi0
acpihpet0 at acpi0: 14318179 Hz
acpimadt0 at acpi0 addr 0xfee00000: PC-AT compat
cpu0 at mainbus0: apid 0 (boot processor)
cpu0: Intel(R) Xeon(R) CPU 5150 @ 2.66GHz, 2660.38 MHz
cpu0: 
FPU,VME,DE,PSE,TSC,MSR,PAE,MCE,CX8,APIC,SEP,MTRR,PGE,MCA,CMOV,PAT,PSE36,CFLUSH,DS,ACPI,MMX,FXSR,SSE,SSE2,SS,HTT,TM,PBE,SSE3,DT
ES64,MWAIT,DS-CPL,VMX,EST,TM2,SSSE3,CX16,xTPR,PDCM,DCA,NXE,LONG,LAHF,PERF
cpu0: 4MB 64b/line 16-way L2 cache
cpu0: smt 0, core 0, package 0
mtrr: Pentium Pro MTRR support, 8 var ranges, 88 fixed ranges
cpu0: apic clock running at 332MHz
cpu0: mwait min=64, max=64, C-substates=0.2.0.0.0, IBE
cpu1 at mainbus0: apid 1 (application processor)
cpu1: Intel(R) Xeon(R) CPU 5150 @ 2.66GHz, 2660.00 MHz
cpu1: 
FPU,VME,DE,PSE,TSC,MSR,PAE,MCE,CX8,APIC,SEP,MTRR,PGE,MCA,CMOV,PAT,PSE36,CFLUSH,DS,ACPI,MMX,FXSR,SSE,SSE2,SS,HTT,TM,PBE,SSE3,DT
ES64,MWAIT,DS-CPL,VMX,EST,TM2,SSSE3,CX16,xTPR,PDCM,DCA,NXE,LONG,LAHF,PERF
cpu1: 4MB 64b/line 16-way L2 cache
cpu1: smt 0, core 1, package 0
cpu2 at mainbus0: apid 7 (application processor)
cpu2: Intel(R) Xeon(R) CPU 5150 @ 2.66GHz, 2659.99 MHz
cpu2: 
FPU,VME,DE,PSE,TSC,MSR,PAE,MCE,CX8,APIC,SEP,MTRR,PGE,MCA,CMOV,PAT,PSE36,CFLUSH,DS,ACPI,MMX,FXSR,SSE,SSE2,SS,HTT,TM,PBE,SSE3,DT
ES64,MWAIT,DS-CPL,VMX,EST,TM2,SSSE3,CX16,xTPR,PDCM,DCA,NXE,LONG,LAHF,PERF
cpu2: 4MB 64b/line 16-way L2 cache
cpu2: smt 0, core 1, package 3
cpu3 at mainbus0: apid 6 (application processor)
cpu3: Intel(R) Xeon(R) CPU 5150 @ 2.66GHz, 2659.99 MHz
cpu3: 
FPU,VME,DE,PSE,TSC,MSR,PAE,MCE,CX8,APIC,SEP,MTRR,PGE,MCA,CMOV,PAT,PSE36,CFLUSH,DS,ACPI,MMX,FXSR,SSE,SSE2,SS,HTT,TM,PBE,SSE3,DT
ES64,MWAIT,DS-CPL,VMX,EST,TM2,SSSE3,CX16,xTPR,PDCM,DCA,NXE,LONG,LAHF,PERF
cpu3: 4MB 64b/line 16-way L2 cache
cpu3: smt 0, core 0, package 3
ioapic0 at mainbus0: apid 8 pa 0xfec00000, version 20, 24 pins
acpimcfg0 at acpi0 addr 0xd0000000, bus 0-255
acpiprt0 at acpi0: bus 0 (PCI0)
acpiprt1 at acpi0: bus 1 (P0P1)
acpiprt2 at acpi0: bus 2 (P1P2)
acpiprt3 at acpi0: bus 5 (P2P5)
acpiprt4 at acpi0: bus 3 (P2P3)
acpiprt5 at acpi0: bus 15 (RP04)
acpiprt6 at acpi0: bus 16 (PCIB)
acpiprt7 at acpi0: bus 8 (NRP4)
acpiprt8 at acpi0: bus 12 (SRP1)
acpiprt9 at acpi0: bus 14 (SRP3)
acpicpu0 at acpi0: C1
acpicpu1 at acpi0: C1
acpicpu2 at acpi0: C1
acpicpu3 at acpi0: C1
acpibtn0 at acpi0: PWRB
memory map conflict 0xfff90000/0x30000
pci0 at mainbus0 bus 0
pchb0 at pci0 dev 0 function 0 "Intel 5000X Host" rev 0x30
ppb0 at pci0 dev 2 function 0 "Intel 5000 PCIE x8" rev 0x30
pci1 at ppb0 bus 1
ppb1 at pci1 dev 0 function 0 "Intel 6321ESB PCIE" rev 0x01
pci2 at ppb1 bus 2
ppb2 at pci2 dev 0 function 0 "Intel 6321ESB PCIE" rev 0x01: msi
pci3 at ppb2 bus 3
ppb3 at pci2 dev 1 function 0 "Intel 6321ESB PCIE" rev 0x01: msi
pci4 at ppb3 bus 4
ppb4 at pci2 dev 2 function 0 "Intel 6321ESB PCIE" rev 0x01
pci5 at ppb4 bus 5
em0 at pci5 dev 0 function 0 "Intel 80003ES2" rev 0x01: msi, address 
00:17:f2:03:41:94
em1 at pci5 dev 0 function 1 "Intel 80003ES2" rev 0x01: msi, address 
00:17:f2:03:41:95
"Intel 6321ESB IOxAPIC" rev 0x01 at pci1 dev 0 function 1 not configured
ppb5 at pci1 dev 0 function 3 "Intel 6321ESB PCIE-PCIX" rev 0x01
pci6 at ppb5 bus 6
pchb1 at pci0 dev 3 function 0 "Intel 5000 PCIE" rev 0x30
ppb6 at pci0 dev 4 function 0 "Intel 5000 PCIE x16" rev 0x30: msi
pci7 at ppb6 bus 8
vga1 at pci7 dev 0 function 0 "NVIDIA GeForce 7300 GT" rev 0xa1
wsdisplay0 at vga1 mux 1: console (80x25, vt100 emulation)
wsdisplay0: screen 1-5 added (80x25, vt100 emulation)
pchb2 at pci0 dev 5 function 0 "Intel 5000 PCIE" rev 0x30
pchb3 at pci0 dev 6 function 0 "Intel 5000 PCIE" rev 0x30
pchb4 at pci0 dev 7 function 0 "Intel 5000 PCIE" rev 0x30
"Intel I/OAT" rev 0x30 at pci0 dev 8 function 0 not configured
pchb5 at pci0 dev 16 function 0 "Intel 5000 Error Reporting" rev 0x30
pchb6 at pci0 dev 16 function 1 "Intel 5000 Error Reporting" rev 0x30
pchb7 at pci0 dev 16 function 2 "Intel 5000 Error Reporting" rev 0x30
pchb8 at pci0 dev 17 function 0 "Intel 5000 Reserved" rev 0x30
pchb9 at pci0 dev 19 function 0 "Intel 5000 Reserved" rev 0x30
pchb10 at pci0 dev 21 function 0 "Intel 5000 FBD" rev 0x30
pchb11 at pci0 dev 22 function 0 "Intel 5000 FBD" rev 0x30
azalia0 at pci0 dev 27 function 0 "Intel 6321ESB HD Audio" rev 0x09: msi
azalia0: codecs: Realtek ALC885
audio0 at azalia0
ppb7 at pci0 dev 28 function 0 "Intel 6321ESB PCIE" rev 0x09: msi
pci8 at ppb7 bus 12
ppb8 at pci0 dev 28 function 1 "Intel 6321ESB PCIE" rev 0x09: msi
pci9 at ppb8 bus 13
ppb9 at pci0 dev 28 function 2 "Intel 6321ESB PCIE" rev 0x09: msi
pci10 at ppb9 bus 14
ppb10 at pci0 dev 28 function 3 "Intel 6321ESB PCIE" rev 0x09: msi
pci11 at ppb10 bus 15
uhci0 at pci0 dev 29 function 0 "Intel 6321ESB USB" rev 0x09: apic 8 int 19
uhci1 at pci0 dev 29 function 1 "Intel 6321ESB USB" rev 0x09: apic 8 int 20
uhci2 at pci0 dev 29 function 2 "Intel 6321ESB USB" rev 0x09: apic 8 int 21
uhci3 at pci0 dev 29 function 3 "Intel 6321ESB USB" rev 0x09: apic 8 int 22
ehci0 at pci0 dev 29 function 7 "Intel 6321ESB USB" rev 0x09: apic 8 int 19
usb0 at ehci0: USB revision 2.0
uhub0 at usb0 "Intel EHCI root hub" rev 2.00/1.00 addr 1
ppb11 at pci0 dev 30 function 0 "Intel 82801BA Hub-to-PCI" rev 0xd9
pci12 at ppb11 bus 16
"TI TSB82AA2 FireWire" rev 0x01 at pci12 dev 11 function 0 not configured
pcib0 at pci0 dev 31 function 0 "Intel 6321ESB LPC" rev 0x09
pciide0 at pci0 dev 31 function 1 "Intel 6321ESB IDE" rev 0x09: DMA, channel 0 
configured to native-PCI, channel 1 configured to nat
ive-PCI
pciide0: using apic 8 int 20 for native-PCI interrupt
atapiscsi0 at pciide0 channel 0 drive 0
scsibus1 at atapiscsi0: 2 targets
cd0 at scsibus1 targ 0 lun 0: <PIONEER, DVD-RW DVR-111D, AB09> ATAPI 5/cdrom 
removable
cd0(pciide0:0:0): using PIO mode 4, Ultra-DMA mode 4
pciide0: channel 1 disabled (no drives)
pciide1 at pci0 dev 31 function 2 "Intel 6321ESB SATA" rev 0x09: DMA, channel 0 
configured to native-PCI, channel 1 configured to na
tive-PCI
pciide1: using apic 8 int 21 for native-PCI interrupt
wd0 at pciide1 channel 0 drive 0: <ST3160812AS P>
wd0: 16-sector PIO, LBA48, 152627MB, 312581808 sectors
wd0(pciide1:0:0): using PIO mode 4, Ultra-DMA mode 6
wd1 at pciide1 channel 1 drive 0: <ST3000VX000-9YW166>
wd1: 16-sector PIO, LBA48, 2861588MB, 5860533168 sectors
wd1(pciide1:1:0): using PIO mode 4, Ultra-DMA mode 6
ichiic0 at pci0 dev 31 function 3 "Intel 6321ESB SMBus" rev 0x09: apic 8 int 21
iic0 at ichiic0
usb1 at uhci0: USB revision 1.0
uhub1 at usb1 "Intel UHCI root hub" rev 1.00/1.00 addr 1
usb2 at uhci1: USB revision 1.0
uhub2 at usb2 "Intel UHCI root hub" rev 1.00/1.00 addr 1
usb3 at uhci2: USB revision 1.0
uhub3 at usb3 "Intel UHCI root hub" rev 1.00/1.00 addr 1
usb4 at uhci3: USB revision 1.0
uhub4 at usb4 "Intel UHCI root hub" rev 1.00/1.00 addr 1
isa0 at pcib0
isadma0 at isa0
pcppi0 at isa0 port 0x61
spkr0 at pcppi0
uhub5 at uhub0 port 2 "Apple, Inc. Keyboard Hub" rev 2.00/96.15 addr 2
uhidev0 at uhub5 port 2 configuration 1 interface 0 "Apple, Inc Apple Keyboard" 
rev 2.00/0.69 addr 3
uhidev0: iclass 3/1
ukbd0 at uhidev0: 8 variable keys, 5 key codes, country code 33
wskbd0 at ukbd0: console keyboard, using wsdisplay0
uhidev1 at uhub5 port 2 configuration 1 interface 1 "Apple, Inc Apple Keyboard" 
rev 2.00/0.69 addr 3
uhidev1: iclass 3/0
uhid0 at uhidev1: input=1, output=0, feature=0
uhidev2 at uhub5 port 3 configuration 1 interface 0 "Primax Electronics Apple 
Optical USB Mouse" rev 1.10/1.10 addr 4
uhidev2: iclass 3/1
ums0 at uhidev2: 4 buttons, Z and W dir
wsmouse0 at ums0 mux 0
rum0 at uhub0 port 5 "Cisco-Linksys Compact Wireless-G USB Adapter" rev 
2.00/0.01 addr 5
rum0: MAC/BBP RT2573 (rev 0x2573a), RF RT2528, address 00:18:39:1c:22:7a
vscsi0 at root
scsibus2 at vscsi0: 256 targets
softraid0 at root
scsibus3 at softraid0: 256 targets
root on wd0a (1b370bc9a7444b9f.a) swap on wd0b dump on wd0b

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