> bios0: vendor LENOVO version "N27ET43W (1.29 )" date 08/13/2021
> bios0: LENOVO 20L9001GUS
> acpi0 at bios0: ACPI 5.0
> acpi0: sleep states S0 S3 S4 S5

On the other hand, your BIOS is very new.  So new that it has S0.
These days Microsoft is only testing S0.

Lenovo and some other vendors are re-adding S3, because S0 suspend is a
festering pile of crap which only works in Windows, well barely, on a
good day maybe.

But the S3 re-added is still very new BIOS (SMI?) emulation and it
has glitches.  It will take some time to mature.

You have a tremendous amount of wakeup devices which could be implicated
in this:

acpi0: wakeup devices GLAN(S4) XHC_(S3) XDCI(S4) HDAS(S4) RP01(S4) PXSX(S4) 
RP02(S4) PXSX(S4) PXSX(S4) RP04(S4) PXSX(S4) RP05(S4) PXSX(S4) RP06(S4) 
PXSX(S4) RP07(S4) [...]

Your dmesg lacks tpm0.  You probably disabled it in the BIOS:

"STM7304" at acpi0 not configured

If you re-enable TPM uit in the BIOS, and try a snapshot (or upcoming
7.0) there is a recent fix which may help.  It is a potential reason for
the interrupts...

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