Dear Tabinda,

Fiberfox applies a global scaling factor to the signal that is defined in the 
GUI. I think the default is 100. This is necessary since the image values are 
stored as 'short' variables. You can change this factor however you like.
Furthermore, the signal scales with the voxel volume, as it is the case in real 
MR images. In this case by a factor of 3x3x3 = 27, since the image spacing is 
3mm.
A simulation without relaxation would therefore result in a b=0 signal 
intensity of 2700. The relaxation reduces this to the roughly 800-850 that you 
observed.

Peter

-----Ursprüngliche Nachricht-----
Von: tabinda <tsar...@student.unimelb.edu.au> 
Gesendet: Freitag, 11. Mai 2018 02:23
An: mitk-users@lists.sourceforge.net
Betreff: [mitk-users] Understanding dMRI Simulation using Fiberfox

Hi! 

I am Tabinda. I have been using the Fibercup phantom simulated using 
Mitk-Fiberfox. According to the ball-zeppelin model for phantom simulation 
given in "Fiberfox: Facilitating the Creation of Realistic White Matter 
Software Phantoms" (image attached), the isotropic compartment should not be 
having high intensity. 

<http://mitk-users.1123740.n5.nabble.com/file/t737/zbmodel.png> 

According to the equation, the isotropic compartment is given as
fv*exp(b*D1) where fv is the volume fraction for isotropic compartment, b is 
the b-value and D1 is the isotropic diffusion. Calculating these value results 
using the parameters provided in the paper gives 0.033 whereas the simulated 
phantom (B2.nii.gz- region outside the fibers) has the intensities between 
800-850. Even after the simulation of k-space (equation attached-fraction of 
the simulated signal), how come the isotropic compartment ends up with high 
intensities?

<http://mitk-users.1123740.n5.nabble.com/file/t737/kspace.png> 

Is there something which I am missing?

Your timely response will be highly appreciated

Thanks,
Tabinda




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