mpiblast works well for me, but I've recently encountered a sequence which seems to trip it up badly. The 5M sequence is available from ncbi as gi=49175990

Here is a direct link to its fasta
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&qty=1&c_start=1&list_uids=49175990&uids=&dopt=fasta&dispmax=5&sendto=t&from=begin&to=end

The problem reproduces on 3 different small clusters (4 to 8 nodes) using slightly different blastable databases (nt or nt+refseq). I'm continuing to diagnose, but was hoping that a few folks on this list might be able to confirm that it works/fails for them. If so please indicate your number of nodes and your blastable database.

Thank you,
Mike Cariaso

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