When we increase the number of connections our 3.22.25 server 'hangs':

mysql> show status;
No connection. Trying to reconnect...
ERROR 1129: Host 'xxx is blocked because of many connection er
rors.  Unblock with 'mysqladmin flush-hosts'
ERROR: Can't connect to the server

This happens when we increase MaxClients on the Apache webserver from 200 to
220 resulting in more queries to the db-server. After a few hours the
db-server hangs with the above error. DB and apache server run on different
machines.
Apache talks with mysql through PHP 4.0.41/ZendOptimizer/Cache.
The max connections on the db-server is set to 400.
Linux.

More info (after restarting mysql):
mysql> show status;
+--------------------------+----------+
| Variable_name            | Value    |
+--------------------------+----------+
| Aborted_clients          | 0        |
| Aborted_connects         | 671      |
| Created_tmp_tables       | 31067    |
| Delayed_insert_threads   | 0        |
| Delayed_writes           | 0        |
| Delayed_errors           | 0        |
| Flush_commands           | 1        |
| Handler_delete           | 221      |
| Handler_read_first       | 23       |
| Handler_read_key         | 1413111  |
| Handler_read_next        | 26516553 |
| Handler_read_rnd         | 4318261  |
| Handler_update           | 85123    |
| Handler_write            | 182257   |
| Key_blocks_used          | 15641    |
| Key_read_requests        | 6039569  |
| Key_reads                | 50309    |
| Key_write_requests       | 3213     |
| Key_writes               | 3005     |
| Max_used_connections     | 222      |
| Not_flushed_key_blocks   | 0        |
| Not_flushed_delayed_rows | 0        |
| Open_tables              | 63       |
| Open_files               | 6        |
| Open_streams             | 0        |
| Opened_tables            | 6547     |
| Questions                | 361413   |
| Running_threads          | 220      |
| Slow_queries             | 6        |
| Uptime                   | 2048     |
+--------------------------+----------+
30 rows in set (0.00 sec)

Anyone have a clue whats going on ?


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