Id Study keyword
1  A    K1
2  A    K2
3  B    K1
4  B    K2
5  C    K1
6  C    k3

SELECT DISTINCT Study FROM yourtablename WHERE keyword='K1' AND NOT keyword='K2'


That *should* give you a single entry for 'C' since its keywords do not match both 'K1' *and* 'K2'

But your posting *was* a little confusing, so perhaps you can elaborate a little further on what it is you're trying to accomplish?

-id


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