It's been extremely effective in blocking spam sent by spambots on
large ISPs.  It's not a magic anti-spam bullet.  (If you know one,
please let us know.)

That simply hasn't been my experience. I still get lots of spam from booted 
hosts in large provider networks, and yes, that includes many that block 25. As 
near as I can tell, 25 blocking is not affecting spammers at all, just 
legitimate users.

I know people at large ISPs with actual data. Port 25 blocking is quite effective.

R's,
John


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