Alternatively, you can also use discrete BJT's or MOSFET's to drive your 
cathodes. If you have a multiplexed design (so you would e.g. only need them 
for driving 2 nixies at a time in a 6 digit clock) it's quite doable and 
probably cheaper/simpler/cleaner than using that HVXXXX chip + level shifters. 
You can also consider using the SN75468, with a zener on the common (pin 9), as 
shown here: 
http://lucsmall.com/2011/07/19/using-the-sn75468-as-a-nixie-tube-driver/

If you don't have enough pins on your MCU, you'd need a shift register (e.g. a 
74595). Or just get an MCU with more pins, they're cheap anyway.

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