Sure. Except for my phone, I don't use anything but NetBSD. I've got it on my laptop and desktop.
my desktop is an i7-5280k which I use with an nvidia gtx 770, and the (outdated) laptop is a dell inspiron n4030 with many parts replaced. I usually run firefox listening to youtube for music or watching twitch streams, a couple of terminal emulators for email/irc, read PDFs with evince3, type homework with LyX, and do numerical analysis with Octave (like MATLAB). Sometimes I need to open things made with Microsoft Office so there's LibreOffice for those, or (rarely) google docs. Small things are worse. - worse access to closed source software. I've been a linux user before so I am already accustomed to using the open variants. NetBSD has some linux compat / wine on i386, but it's worse. Linux has some good Steam games which I miss, but I'm told that we're good on the console emulators front, so I should try those sometime. - hardware support is more hit and miss. for working wifi on my laptop, I switched the internal card for a supported intel 7260 card. I heard changing cards isn't possible on all laptops, but it was on mine. Previously I used a USB one (Edimax EW-78211Un, I believe) - it was worse, but works. Before that, I used my phone via USB tether (urndis), and I heard it's possible to bluetooth tether, but I haven't got around to try it. My laptop works almost perfectly (bluetooth, graphical acceleration, suspend...) but it's an older one, newer ones are worse. - netbsd, to put it lightly, is less user friendly. I only accidentally discovered how to suspend. it reminds me of Gentoo.