By the authority vested in me as President by the Constitution and the laws of
the United States of America, it is hereby ordered:
Section 1. Purpose. From the founding of our Republic, scientific discovery
and technological innovation have driven American progress and prosperity.
Today, America is in a race for global technology dominance in the development
of artificial intelligence (AI), an important frontier of scientific discovery
and economic growth. To that end, my Administration has taken a number of
actions to win that race, including issuing multiple Executive Orders and
implementing America’s AI Action Plan, which recognizes the need to invest in
AI-enabled science to accelerate scientific advancement. In this pivotal
moment, the challenges we face require a historic national effort, comparable
in urgency and ambition to the Manhattan Project that was instrumental to our
victory in World War II and was a critical basis for the foundation of the
Department of Energy (DOE) and its national laboratories.
This order launches the “Genesis Mission” as a dedicated, coordinated national
effort to unleash a new age of AI‑accelerated innovation and discovery that can
solve the most challenging problems of this century. The Genesis Mission will
build an integrated AI platform to harness Federal scientific datasets — the
world’s largest collection of such datasets, developed over decades of Federal
investments — to train scientific foundation models and create AI agents to
test new hypotheses, automate research workflows, and accelerate scientific
breakthroughs. The Genesis Mission will bring together our Nation’s research
and development resources — combining the efforts of brilliant American
scientists, including those at our national laboratories, with pioneering
American businesses; world-renowned universities; and existing research
infrastructure, data repositories, production plants, and national security
sites — to achieve dramatic acceleration in AI development and utilization. We
will harness for the benefit of our Nation the revolution underway in
computing, and build on decades of innovation in semiconductors and
high-performance computing. The Genesis Mission will dramatically accelerate
scientific discovery, strengthen national security, secure energy dominance,
enhance workforce productivity, and multiply the return on taxpayer investment
into research and development, thereby furthering America’s technological
dominance and global strategic leadership.
Sec. 2. Establishment of the Genesis Mission. (a) There is hereby
established the Genesis Mission (Mission), a national effort to accelerate the
application of AI for transformative scientific discovery focused on pressing
national challenges.
(b) The Secretary of Energy (Secretary) shall be responsible for implementing
the Mission within DOE, consistent with the provisions of this order,
including, as appropriate and authorized by law, setting priorities and
ensuring that all DOE resources used for elements of the Mission are integrated
into a secure, unified platform. The Secretary may designate a senior
political appointee to oversee day-to-day operations of the Mission.
(c) The Assistant to the President for Science and Technology (APST) shall
provide general leadership of the Mission, including coordination of
participating executive departments and agencies (agencies) through the
National Science and Technology Council (NSTC) and the issuance of guidance to
ensure that the Mission is aligned with national objectives.
Sec. 3. Operation of the American Science and Security Platform. (a) The
Secretary shall establish and operate the American Science and Security
Platform (Platform) to serve as the infrastructure for the Mission with the
purpose of providing, in an integrated manner and to the maximum extent
practicable and consistent with law:
(i) high-performance computing resources, including DOE national laboratory
supercomputers and secure cloud-based AI computing environments, capable of
supporting large-scale model training, simulation, and inference;
(ii) AI modeling and analysis frameworks, including AI agents to explore
design spaces, evaluate experimental outcomes, and automate workflows;
(iii) computational tools, including AI-enabled predictive models, simulation
models, and design optimization tools;
(iv) domain-specific foundation models across the range of scientific domains
covered;
(v) secure access to appropriate datasets, including proprietary, federally
curated, and open scientific datasets, in addition to synthetic data generated
through DOE computing resources, consistent with applicable law; applicable
classification, privacy, and intellectual property protections; and Federal
data-access and data-management standards; and
(vi) experimental and production tools to enable autonomous and AI-augmented
experimentation and manufacturing in high-impact domains.
(b) The Secretary shall take necessary steps to ensure that the Platform is
operated in a manner that meets security requirements consistent with its
national security and competitiveness mission, including applicable
classification, supply chain security, and Federal cybersecurity standards and
best practices.
(c) Within 90 days of the date of this order, the Secretary shall identify
Federal computing, storage, and networking resources available to support the
Mission, including both DOE on-premises and cloud-based high-performance
computing systems, and resources available through industry partners. The
Secretary shall also identify any additional partnerships or infrastructure
enhancements that could support the computational foundation for the Platform.
(d) Within 120 days of the date of this order, the Secretary shall:
(i) identify a set of initial data and model assets for use in the Mission,
including digitization, standardization, metadata, and provenance tracking; and
(ii) develop a plan, with appropriate risk-based cybersecurity measures, for
incorporating datasets from federally funded research, other agencies, academic
institutions, and approved private-sector partners, as appropriate.
(e) Within 240 days of the date of this order, the Secretary shall review
capabilities across the DOE national laboratories and other participating
Federal research facilities for robotic laboratories and production facilities
with the ability to engage in AI-directed experimentation and manufacturing,
including automated and AI-augmented workflows and the related technical and
operational standards needed.
(f) Within 270 days of the date of this order, the Secretary shall, consistent
with applicable law and subject to available appropriations, seek to
demonstrate an initial operating capability of the Platform for at least one of
the national science and technology challenges identified pursuant to section 4
of this order.
Sec. 4. Identification of National Science and Technology Challenges. (a)
Within 60 days of the date of this order, the Secretary shall identify and
submit to the APST a detailed list of at least 20 science and technology
challenges of national importance that the Secretary assesses to have potential
to be addressed through the Mission and that span priority domains consistent
with National Science and Technology Memorandum 2 of September 23, 2025,
including:
(i) advanced manufacturing;
(ii) biotechnology;
(iii) critical materials;
(iv) nuclear fission and fusion energy;
(v) quantum information science; and
(vi) semiconductors and microelectronics.
(b) Within 30 days of submission of the list described in subsection (a) of
this section, the APST shall review the proposed list and, working with
participating agency members of the NSTC, coordinate the development of an
expanded list that can serve as the initial set of national science and
technology challenges to be addressed by the Mission, including additional
challenges proposed by participating agencies through the NSTC, subject to
available appropriations.
(c) Following development of the expanded list described in subsection (b) of
this section, agencies participating in the Mission shall use the Platform to
advance research and development aligned with the national science and
technology challenges identified in the expanded list, consistent with
applicable law and their respective missions, and subject to available
appropriations.
(d) On an annual basis thereafter, the Secretary shall review and update the
list of challenges in consultation with the APST and the NSTC to reflect
progress achieved, emerging national needs, and alignment with my
Administration’s research and development priorities.
Sec. 5. Interagency Coordination and External Engagement. (a) The APST,
through the NSTC, and with support from the Federal Chief Data Officer Council
and the Chief AI Officer Council, shall convene relevant and interested
agencies to:
(i) assist participating agencies in aligning, to the extent permitted by
law, their AI-related programs, datasets, and research and development
activities with the objectives of the Mission in their respective areas of
expertise, while avoiding duplication of effort across the Federal Government
and promoting interoperability;
(ii) identify data sources that may support the Mission’s aim;
(iii) develop a process and resourcing plan in coordination with participating
agencies for integrating appropriate and available agency data and
infrastructure into the Mission, to the extent permitted by law and subject to
available appropriations, including methods under which all agencies
contributing to the Mission are encouraged to implement appropriate risk-based
security measures that reflect cybersecurity best practices;
(iv) launch coordinated funding opportunities or prize competitions across
participating agencies, to the extent permitted by law and subject to available
appropriations, to incentivize private-sector participation in AI-driven
scientific research aligned with Mission objectives; and
(v) establish mechanisms to coordinate research and development funding
opportunities and experimental resources across participating agencies,
ensuring agencies can participate effectively in the Mission.
(b) The APST shall coordinate with relevant agencies in establishing,
consistent with existing authorizing statutes and subject to available
appropriations, competitive programs for research fellowships, internships, and
apprenticeships focused on the application of AI to scientific domains
identified as national challenges for the Mission, to include placement of
program participants at DOE national laboratories and other participating
Federal research facilities, with the purpose of providing access to the
Platform and training in AI-enabled scientific discovery.
(c) The Secretary, in coordination with the APST and the Special Advisor for
AI and Crypto, shall establish mechanisms for agency collaboration with
external partners possessing advanced AI, data, or computing capabilities or
scientific domain expertise, including through cooperative research and
development agreements, user facility partnerships, or other appropriate
arrangements with external entities to support and enhance the activities of
the Mission, and shall ensure that such partnerships are structured to preserve
the security of Federal research assets and maximize public benefit. To
facilitate these collaborations, the Secretary shall:
(i) develop standardized partnership frameworks, including cooperative
research and development or other appropriate agreements, and data-use and
model‑sharing agreements;
(ii) establish clear policies for ownership, licensing, trade-secret
protections, and commercialization of intellectual property developed under the
Mission, including innovations arising from AI-directed experiments;
(iii) implement uniform and stringent data access and management processes and
cybersecurity standards for non-Federal collaborators accessing datasets,
models, and computing environments, including measures requiring compliance
with classification, privacy, and export-control requirements, as well as other
applicable laws; and
(iv) establish procedures to ensure the highest standards of vetting and
authorization of users and collaborators seeking access to the resources of the
Mission and associated research activities, including the Platform and
associated Federal research resources.
(d) The APST, through the NSTC, shall, to the extent appropriate, identify
opportunities for international scientific collaboration to support activities
under the Mission.
Sec. 6. Evaluation and Reporting. (a) Within 1 year of the date of this
order, and on an annual basis thereafter, the Secretary shall submit a report
to the President, through the APST and the Director of the Office of Management
and Budget, describing:
(i) the Platform’s operational status and capabilities;
(ii) progress toward integration across DOE national laboratories and other
participating Federal research partners, including shared access to computing
resources, data infrastructure, and research facilities;
(iii) the status of user engagement, including participation of student
researchers and any related training;
(iv) updates on research efforts and outcomes achieved, including measurable
scientific advances, publications, and prototype technologies;
(v) the scope and outcomes of public-private partnerships, including
collaborative research projects and any technology transitions or
commercialization activities; and
(vi) any identified needs or recommendations for authorities or interagency
support to achieve the Mission’s objectives.
Sec. 7. General Provisions. (a) Nothing in this order shall be construed to
impair or otherwise affect:
(i) the authority granted by law to an executive department or agency, or the
head thereof; or
(ii) the functions of the Director of the Office of Management and Budget
relating to budgetary, administrative, or legislative proposals.
(b) This order shall be implemented consistent with applicable law and subject
to the availability of appropriations.
(c) This order is not intended to, and does not, create any right or benefit,
substantive or procedural, enforceable at law or in equity by any party against
the United States, its departments, agencies, or entities, its officers,
employees, or agents, or any other person.
(d) The costs for publication of this order shall be borne by the Department
of Energy.
DONALD J. TRUMP
THE WHITE HOUSE,
November 24, 2025.
<https://www.whitehouse.gov/presidential-actions/2025/11/launching-the-genesis-mission/>
