Yes I found a solution in my answer here:

https://serverfault.com/questions/1002021/nginx-fails-on-high-load-with-debian10-and-not-with-debian9

accept_mutex changed from on to off in the default value. Setting it back to
"on" and Nginx is happily running with 10k requests per second again. I
guess it is a combination of multi_accept and accept_mutex which caused my
troubles.

regards
Janning

Posted at Nginx Forum: 
https://forum.nginx.org/read.php?2,286893,292394#msg-292394

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