It kind of depends on what you want to do with the pictures. When I was taking pictures for the school paper I used TriX developed in Acufine for ASA 1,200 in a Mamiya-Sekor 1000TL with a 50mm f/1.8 lens. The local legend photographer (more than local, award winning) used a twin lens Rollei and Royal-X at ASA 1,000. The lighting was incandescent back then at Hinkle Fieldhouse, but I got usable images for the school paper and he won AP awards. TMZ pushed to 6,400 is excellent and even allows you to consider depth of field with bazooka-like lenses, but it kind of falls apart if you try for 16x20s. Sure is easy to focus on the grain, though.