* History * The earliest documentation of blood transfusion is found in the
religious text of many civilizations. The first documented demonstration of
blood transfusion was between two dogs by Richard Lower in 1665.
Landsteener discovered the ABO Blood Group system in 1901, which is one of
the most important landmark discoveries in the Transfusion Medicine. In the
1970s voluntary donors were accepted as blood donors. These donors were
later on found to people having high-risk activities and the recipients were
found to be suffering from liver diseases. This lead to another discovery of
Hepatitis B transmitted by donated blood. Since then testing for the
hepatitis B antigen was implemented and this together with cessation of paid
donors reduced the incidence of post transfusion hepatitis. Further studies
also made us to include tests for Malaria, Syphilis, AIDS, and Hepatitis C
to make the donated blood as safe as possible to the recipient.
* What is blood?*
One can almost say that blood is that magic potion which gives life to
another person. Though we have made tremendous discoveries and inventions in
Science we are not yet able to make the magic potion called Blood. Human
blood has no substitute. Requirement of safe blood is increasing and regular
voluntary blood donations are vital for blood transfusion services.
* Who can donate blood? *
Eligibility criteria for blood donation
Donor should be between 18-55 years of age with a weight of 50 kg or above
with pulse rate, body temperature and blood pressure should be normal. Both
men and women can donate. There are only few conditions in which donors are
permanently excluded. The donor with history of epilepsy, psychotic
disorders, abnormal bleeding tendencies, severe asthma, cardiovascular
disorders, malignancy are permanently unfit for blood donation. Donors
suffering from disease like hepatitis, malaria, measles, mumps, and syphilis
may donate blood after full recovery with 3-6 months gap. Also people who
have undergone surgery, blood transfusion may safely donate blood after 6-12
mths for woman donors who are pregnant or lactating blood is not taken as
their iron reserves are already on the lower side.
* How much blood can be taken?*
Our body has 5.5 ltr of blood of which only 350 ml - 450 ml of blood is
taken depending upon weight of donor. Majority of healthy adults can
tolerate withdrawal of one unit of blood. The withdrawn blood volume is
restored within 24 hours and the hemoglobin and cell components are restored
in 2 months. Therefore it is safe to donate blood every three months.
* What is done with the blood collected?*
The blood collected in sterile, pyrogen free containers with anticoagulants
like CPDA or CPDA with SAGM. This prevents clotting and provides nutrition
for the cells. This blood is stored at 2-6 C or -20 C depending on the
component prepared. Donated blood undergoes various tests like blood
grouping antibody detection, testing of infections like hepatitis, AIDS,
Malaria, syphilis and before it reaches the recipient it undergoes
compatibility testing with the recipient blood.
* Modern Blood Transfusion Practice:*
Modern blood transfusion basically deals with the optimal use of one unit of
blood. One unit of whole blood is separated into components making it
available to different patients according to their requirement. Thus one
unit of blood is converted into packed cell volume, fresh frozen plasma,
platelet concentrate, cryoprecipitate and granulocytes concentrate.
Another important practice is apheresis. This is separation of only desired
component from the donor and return the remaining constituent back to donor.
This technique is also used for remaining pathological substance in
patients.

Withdrawal of blood for transfusion is regarded as a safe procedure now and
blood donor has emerged as the single most vital link.

So this year my dear friends '*Donate Blood*' and give somebody a *GIFT OF
LIFE*.

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