Researchers map 5,000 proteins in a stem cell 

Researchersin Germany have mapped over 5,000 proteins present in embryonic 
stemcells in a bid to understand the mechanism of their conversion intoother 
cells. Questions on how stem cells operate and convert into othercells have 
prompted researchers to take a "big picture" approach,identifying all the 
proteins that are expressed in stem cells.Currently, around 1,700 proteins have 
been identified in stem cellsthat hold great potential in biology and medicine. 

Now, usingmass spectrometry and special "heavy" amino acids, Matthias Mann 
andcolleagues at the Max-Planck-Institute for Biochemistry in Germany 
havequantified 5,111 distinct mouse stem cell proteins. As expected, a 
goodportion of these proteins are involved in rapid cell growth, butoverall the 
protein map encompassed a broad range of cell functions. 
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