The increase in memory consumption doesn't impact runtime positively or negatively, unless of course your system doesn't have enough physical memory to accommodate the increase. NONMEM's memory footprint is directly related to the buffer values in the SIZES file, as you increase the values the memory footprint increases to accommodate.

In the end processor speed is really the only thing that positively or negatively effects NONMEM runtime.

Leonid Gibiansky wrote:
Dear All,
I noticed that the Nonmem installed with NMQUAL "big nm6" defaults
instead of the standard ones results in approximately 10-times increase
in the memory required to run Nonmem (on my recent problem, from 12 MB
to 140 MB). I am wondering whether anybody checked how this influences
the run time. Is it better (in terms of the run time) to use standard
sizes, or "big" is OK if you have enough RAM?
Thanks!
Leonid


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Darin Perusich
Unix Systems Administrator
Cognigen Corporation
395 Youngs Rd.
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