Dear Martin and Elodie and others, Thanks for pointing out this nice function of PsN-- I think I will give it a try this time.
________________________________ From: Martin Bergstrand <martin.bergstr...@farmbio.uu.se> To: Sebastian Ueckert <sebastian.ueck...@googlemail.com>; Ethan Wu <ethan.w...@yahoo.com> Cc: nmusers@globomaxnm.com Sent: Friday, February 6, 2009 5:52:09 AM Subject: RE: [NMusers] simulation question Dear all, PsN is useful tool for this purpose but I think that the functionality that should be used is called “Stochastic Simulation and Estimation (SSE)”. The Bootstrap functionality is primarily used for obtaining parameter uncertainties. A detailed userguide for the SSE functionality is presented at the PsN webpage (see link below). http://psn.sourceforge.net/PDF_docs/sse_userguide.pdf Write to the PsN mailing list if you experience any troubles and need help (psn-gene...@lists.sourceforge.net). Best regards, Martin From:owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Sebastian Ueckert Sent: Friday, February 06, 2009 10:51 To: Ethan Wu Cc: nmusers@globomaxnm.com Subject: Re: [NMusers] simulation question Dear Ethan, the simplest solution to solve your problem would be to use the bootstrap command of PSN (http://psn.sourceforge.net/). With PSN installed you would simply do: bootstrap final_model.mod -samples=200 PSN would take care of unsuccessful runs and provide a nice summary of the individual estimates. Best regards Sebastian On Thu, Feb 5, 2009 at 11:18 PM, Ethan Wu <ethan.w...@yahoo.com> wrote: Dear users, I am trying to compare several specific PK/PD study designs by: -- run 200 simulations with the final model (develope from original dataset) -- fit the final model to the 200 simulated dataset To achieve above, I used $SIM SUBPROB=200 option however, nonmem would completely stop after running into estimation problem at one specific simulation/estimation cycles, for some designs it stop even before 10th iterations. Is there anyway nonmem could continue go on? Or, does someone know alternative way to achieve the goal? thanks
