Pavel: If you do not mind sharing your control stream file, and if necessary, your data file (or a truncated version of it), perhaps you could send it to me. I may be able to determine if there is a way to modify the control stream code to avoid these errors, or if there is a bug.
Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel: (215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.icondevsolutions.com ________________________________ From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of non...@optonline.net Sent: Thursday, February 03, 2011 9:32 AM To: Martin Johnson Cc: nmusers@globomaxnm.com Subject: Re: [NMusers] error message 0VAR-COV OF SOME OBS ESTIMATED TO BE 0 - a bug? Thank you Martin, It was helpful and educational, but did not resolve the issue. I just used a very different code and datasets. The only common part was $EST MAXEVALS=9999 SIG=5 NOABORT PRINT=1 SORT METHOD=IMP CTYPE=3 NITER=1000 ISAMPLE=300 POSTHOC INTERACTION There are no warnings or errors. Newertheless, the code creates 2 out of 4 requested output files. Both output files are truncated, i.e. after a certain subject and a timepoint there are no output records. It does not depend on the number of added dummy time points (MDV=1). What can it be? Thanks, Pavel ----- Original Message ----- From: Martin Johnson Date: Friday, January 28, 2011 1:52 am Subject: Re: [NMusers] error message 0VAR-COV OF SOME OBS ESTIMATED TO BE 0 - a bug? To: non...@optonline.net > Dear Pavel, > Just adding my few cents.. > I understand that you are very experienced NMUSER, so this mail > may not > add anything new to you. > > > Error message on FNLETA comes from the posthoc step- "An error > message > from FNLETA indicates that NONMEM has experienced difficulties > obtaining posthoc etas" > Error message on CELS "usually" says that there are some "zero" > predictions. > So, in this way..error message makes some sense... > > However, i have not used IMP with M3 and Laplacian, so i can not > comment > on that. > > One thing may be...model also tries to predict the pk or pd for > zero > time points...that could cause this problem....if so, CALLFL=0 > in the > $ERROR may be of some use > > Regards, > Martin Johnson, > PhD Student, > University of Groningen, > The Netherlands > > > > On 01/28/2011 12:31 AM, non...@optonline.net wrote: > > Hello Nonmem Users, > > > > I am getting an error message: > > 0PROGRAM TERMINATED BY FNLETA > > ERROR IN CELS WITH INDIVIDUAL 2 ID= 1.10050000000000E+01 > > 0VAR-COV OF SOME OBS ESTIMATED TO BE 0 > > MESSAGE ISSUED FROM TABLE STEP > > > > The estimate step is as follows: > > $EST MAXEVALS=9999 SIG=5 NOABORT PRINT=1 SORT > > METHOD=IMP CTYPE=3 NITER=1000 ISAMPLE=300 POSTHOC INTERACTION > > MSFO=KI4H004D.MSF LAPLACIAN > > The code also implements M3. The code runs fine, but it does > not > > create the output data files specified in the table > statements. I > > tried to remove some table statements, changed initial > esimates, added > > the additive component to the error model. Nothing helps. > When I do > > not use M3 and Laplacian, I am getting the output files. I > used M3and > > Laplacian with some other drugs, but I did not use it in > combination > > with METHOD=IMP. Can it be a NONMEM bug? The eror does not > make sense. > > Thanks, > > Pavel > > ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
