Michael,
I do not think you can change observation time, but you can change
infusion duration using
RATE=-2 (in the data file)
D1=THETA(*)*EXP(ETA()) (in the control stream)
Alternative is to exclude data points that are inconsistent with the
profiles.
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
On 6/2/2011 11:44 AM, mdkz...@aol.com wrote:
All:
I have a data set following a constant rate 1-hour infusion where the
time of 1-hour sample is imprecise. In some cases the "1-hr" sample was
taken prior to infusion termination as it was intended; however, in
others it was quite apparently take after the infusion ended. I'm
thinking of modeling with the time of the "1-hr" sample as a "theta".
Does anyone have a NONMEM coding example showing how to do this? Any
other suggestions as to how to handle this would be appreciated as well.
Thanks,
Michael
