Hi Pascal
This is not an error in PsN, this is a feature! NONMEM, by default, recompiles the sizes component of a run before each execution. This can take time, so there is an option to turn it off and use the default sizes (as in NONMEM versions 7.1.x and 6.x) with the "-prdefault" command, i.e. "nmfe72 run1.mod run1.lst -prdefault". PsN allows you to specify these extra NONMEM command line options in the configuration file "psn.conf". If you look in your psn.conf file I suspect you will find something like: [default_options] nmfe_options=prdefault,xmloff In the case you mention below you actually need to recompile the sizes before your NONMEM run, so this "prdefault" option should be removed. In PsN you can do this on the command line using the "-nmfe_options" argument. For example: execute run1.mod -nmfe_options=xmloff Here, I turn off the "prdefault" NONMEM option but keep the "xmloff" option. You can find this information in the following documentation: http://psn.sourceforge.net/pdfdocs/common_options_defaults_versions_psn.pdf http://psn.sourceforge.net/pdfdocs/psn_configuration.pdf Best regards Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 www.farmbio.uu.se/research/researchgroups/pharmacometrics/ From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of pascal.gir...@merckgroup.com Sent: den 12 juli 2012 17:43 To: Kassir Nastya Cc: nmusers@globomaxnm.com; Bauer, Robert; Ekaterina Gibiansky Subject: RE: [NMusers] Error files when using multicore runs and psn ==> Fatal Error: Record SIZES is not valid Hi Nastya, You were right : it is my psn installation that refuses to see something else than $PROB as first line as I just checked by running it directly from nmfe72 .... You cannot stop the progress! Thanks again and Kind regards Pascal From: "Kassir Nastya" <nastya.kas...@umontreal.ca> To: <pascal.gir...@merckgroup.com>, "Bauer, Robert" <robert.ba...@iconplc.com>, <nmusers@globomaxnm.com> Date: 12/07/2012 17:25 Subject: RE: [NMusers] Error files when using multicore runs and psn ==> Fatal Error: Record SIZES is not valid _____ Hi Pascal, I have already used it with NONMEM 72 and it works, but not in psn. $SIZES LIM6=1000 $PROBLEM XXXXXX Best regards, Nastya