Dear NMusers I have a dataset where a majority (53%) of the observations are below the LOQ. As yet, I'm not able to tell you which phase(s) of the profile is affected, but the data is observational and from neonates and is likely to due to low doses (the data is actually of a formulation excipient).
The bioanalysts are exploring ways to improve the sensitivity of the assay, however I was wondering whether in principle there is any impediment to applying the likelihood based methods previously discussed in this forum, when a majority of the data is BLOQ. Your comments are greatly appreciated. Kind regards Hussain Hussain Mulla PhD Senior Research Pharmacist, Paediatric Clinical Pharmacology Department of Pharmacy Glenfield Hospital University Hospitals of Leicester Groby Road Leicester LE39QP England Tel: 0116 2502708 Mobile: 07894958736 ________________________________ This e-mail, including any attached files, may contain confidential and / or privileged information and is intended for the exclusive use of the addressee(s) printed above. If you are not the addressee(s), any unauthorised review, disclosure, reproduction, other dissemination or use of this e-mail, or taking of any action in reliance upon the information contained herein, is strictly prohibited. If this e-mail has been sent to you in error, please return to the sender. No guarantee can be given that the contents of this email are virus free - The University Hospitals of Leicester NHS Trust cannot be held responsible for any failure by the recipient(s) to test for viruses before opening any attachments. The information contained in this e-mail may be the subject of public disclosure under the Freedom of Information Act 2000 - unless legally exempt from disclosure, the confidentiality of this e-mail and your reply cannot be guaranteed. Copyright in this email and any attachments created by us remains vested in the University Hospitals of Leicester NHS Trust.
