Sanofi is looking for a Pharmacometrician in Frankfurt (Germany). See below
for the Job description.
Expert Clinical Pharmacokinetics/ Pharmacometrics (m/f)
Your responsibilities
Provide pharmacometric support to drug development programs within a team
environment at sanofi. The incumbent is expected to perform modeling and
simulation in the area of population PK/PD using clinical data, including the
simulation of study-designs ('trial simulation'); in addition experience with
physiology based PK models (PBPK) would be helpful.
* Population PK/PD (PopPK/PD) is a major aspect of pharmacometrics and
combines methods for processing all available information on the
pharmacokinetics and -dynamics of a substance in a therapeutic area, including
demographic variables, and disease state and progression.
* For PopPK/PD mathematical models of the drug behavior in man start to
be designed based on preclinical data and then are optimized during Phases I to
III.
* Trial Simulation is a method to simulate in silico the outcome of
(clinical) trials using the actual knowledge including the PopPK/PD models, in
order to optimize the trials and to reduce the risk of a negative outcome.
* The use of PBPK within internal and external research and development
programs combines in the model besides the physicochemical properties of the
compound, with anatomical and physiological situations, which are responsible
for the complex ADME processes in the patients.
The incumbent is expected to develop, validate and apply the described models
with adherence to scheduled timelines.
These activities are to be conducted in close interdisciplinary contact with
the other functions involved in the product development (e.g. Clinics,
Pharmacology, Galenics).
Your qualifications
* Necessary is a pharmacometric education, respectively Ph.D. or MD
degree in natural sciences or medicine with mathematics/statistics as a focus.
* Sound actual knowledge and practical experience over several years in
the area of population PK and PK/PD are required. At least 3 years practical
experience in mixed-effect modeling (with NONMEM) should be available,
including post-processing, documentation and assessment of the results.
* Several years of direct experience in clinical drug development would
be helpful in addition.
* English in writing and verbal communication is essential.
* Open minded and committed personality, able to successfully cooperate
in diverse teams.
Our Offer
* A varied and interesting job in a competent team within an
international orientation
* An attractive salary commensurate to your qualifications with an above
average compensation and benefits package (eg. stock option and pension plans)
* As well as considerable support for your further professional and
personal development
Information and online application
https://recruiting.sanofi.de/cms/de/karriere/stellenangebote/job-detailansicht.html?jobDbId=66020&jobDbPVId=375568&ref=10&page=
Dr Diether Rueppel
Sanofi-Aventis Deutschland GmbH
Clinical Pharmacokinetics/Pharmacometrics
Drug Disposition, DSAR
D-65926 Frankfurt / Main
Tel. : +49 69 305 16012
e-mail:
diether.ruep...@sanofi-aventis.com<mailto:diether.ruep...@sanofi-aventis.com>
w: www.sanofi.de<http://www.sanofi.de>
