Dear Pavel, Are you using MATRIX=R when using NONMEM or the default sandwich estimator for the covariance matrix? Most nonlinear regression packages use the equivalent of MATRIX=R in NONMEM. You might try MATRIX=R on the $COV step and then compare to Monolix.
Ken Sent from my iPhone > On Nov 6, 2015, at 8:42 AM, Pavel Belo <non...@optonline.net> wrote: > > unstable in the middle with or without simulated annealing. > > I do not take sides. I just try to understand it. As max/min is frequently > reported in BLAs, it is nice to understand what we report
